网站主页 >> CAS数据库列表 >> 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
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- CAS号:
- 265129-71-3
- 英文名:
- GW7647
- 英文别名:
- GW647;GW7647;CS-761;GW 7647X;GWalpha 7647;GW7647, >=98%;GW7647; GW 7647;GW7647 - CAS 265129-71-3 - Calbiochem;2-(4-(2-(1-CYCLOHEXANEBUTYL)-3-CYCLOHEXYLUREIDO)ETHYL)PHENYLTHIO)-2-METHYLPROPIONIC ACID;2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid
- 中文名:
- 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
- 中文别名:
- GW7647 CALBIOCHEM;2-((4-(2-(3-环己基-1-(4-环己基丁基)脲基)乙基)苯基)硫基)-2-甲基丙酸;2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸;2-[[4-[2-[[(环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫代]-2-甲基丙酸
- CBNumber:
- CB5420133
- 分子式:
- C29H46N2O3S
- 分子量:
- 502.75
- MOL File:
- 265129-71-3.mol
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2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸化学性质
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熔点:
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156 - 157°C
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沸点:
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693.9±55.0 °C(Predicted)
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密度:
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1.12
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储存条件:
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Store at RT
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溶解度:
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DMSO: 16 mg/mL, soluble
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形态:
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White solid
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酸度系数(pKa):
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3.79±0.10(Predicted)
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颜色:
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white
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InChIKey:
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PKNYXWMTHFMHKD-UHFFFAOYSA-N
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2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸性质、用途与生产工艺
GW7647 是一种有效的 PPARα 激动剂，对人 PPARα,PPARγ 和 PPARδ 的 EC50 值分别为 6 nM, 1.1 μM 和 6.2 μM。
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PPARα
6 nM (EC
50
, Human PPARα)
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PPARγ
1.1 μM (EC
50
, Human PPARγ)
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PPARδ
6.2 μM (EC
50
, Human PPARδ)
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GW7647 (1 μM) causes a significant increase of PDZK1 protein expression to 129.7 ± 6.5% of vehicle treated control in Caco2BBE cells in the absence and presence of IL-1β. GW7647 also attenuates the IL-1β-mediated decrease in PDZK1 expression. GW7647 (50 nM) stimulates the PI3K phosphorylation followed by the Akt (Ser473) phosphorylation, which induces NOS1 phosphorylation increased the amounts of NO released in the stripped antral mucosa. GW7647 (50 nM) enhances the initial phase of Ca
2+
-regulated exocytotic events stimulated by ACh in antral mucous cells, but GW7647 alone does not evoke any exocytotic event. GW7647 plus ACh stimulates the effects of wortmannin (50 nM) and AKT-inh (100 nM) on the exocytotic events in antral mucous cells. GW 7647 (100 nM) reduces the AQP9 protein abundance by 43%, but it shows not significant effect at 10 and 1,000 nM in WIF-B9 hepatocytes. GW 7647 (100 nM) causes a 24% reduction in AQP9 protein abundance in HepG2 cells, however, it does not significantly increase the protein abundance of L-FABP in HepG2 hepatocytes.
GW7647 (3 mg/kg per day) does not prevent the development of cardiac hypertrophy, but it prevents the decline in left ventricular ejection fraction in vivo.
2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-13861 | 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
GW7647 | 265129-71-3 | 5mg | 1200元 |
| 2024/01/25 | HY-13861 | 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
GW7647 | 265129-71-3 | 10mM * 1mLin DMSO | 1327元 |
2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
生产厂家
265129-71-3, 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸 相关搜索:
- Intracellular receptor
- 合成有机化合物配体
- 抗体-二抗
- Gene Regulation and Expression
- PPAR and RXR Regulators
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- C29H46N2O3S
- 2-((4-(2-(3-环己基-1-(4-环己基丁基)脲基)乙基)苯基)硫基)-2-甲基丙酸
- GW7647 CALBIOCHEM
- 2-[[4-[2-[[(环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫代]-2-甲基丙酸
- 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
- 265129-71-3
- 2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid
- GW7647 - CAS 265129-71-3 - Calbiochem
- CS-761
- GW7647; GW 7647
- GW647
- GW7647
- 2-(4-(2-(1-CYCLOHEXANEBUTYL)-3-CYCLOHEXYLUREIDO)ETHYL)PHENYLTHIO)-2-METHYLPROPIONIC ACID
- 2-[[4-[2-[[(CYCLOHEXYLAMINO)CARBONYL](4-CYCLOHEXYLBUTYL)AMINO]ETHYL]PHENYL]THIO]-2-METHYLPROPANOIC ACID
- 2-((4-(2-(((Cyclohexylamino)carbonyl)-(4-cyclohexylbutyl)amino)ethyl)phenyl)thio)-2-methylpropanoicacid
- GW 7647X
- GWalpha 7647
- Propanoic acid, 2-[[4-[2-[[(cyclohexylaMino)carbonyl](4-cyclohexylbutyl)aMino]ethyl]phenyl]thio]-2-Methyl-
- GW7647, >=98%
- 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropa