L-165041
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- CAS号:
- 79558-09-1
- 英文名:
- L-165,041
- 英文别名:
- CS-760;100877;L 1q5041;L-165,041;COMPOUND P;L-165041, >=98%;L165041; L 165041;L-165,041 - CAS 79558-09-1 - Calbiochem;2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-;4-[3-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY)PROPOXY]PHENOXYACETIC ACID
- 中文名:
- L-165041
- 中文别名:
- L-165,041 CALBIOCHEM;[4-[3-(4-乙酰基-3-羟基-2-丙基苯氧基)丙氧基]苯氧基]乙酸;2-(4-(3-(4-乙酰基-3-羟基-2-丙基苯氧基)丙氧基)苯氧基)乙酸
- CBNumber:
- CB5422531
- 分子式:
- C22H26O7
- 分子量:
- 402.44
- MOL File:
- 79558-09-1.mol
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L-165041化学性质
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熔点:
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127-128 °C(lit.)
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沸点:
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600.8±55.0 °C(Predicted)
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密度:
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1.222±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >10 mg/mL
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形态:
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solid
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酸度系数(pKa):
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3.23±0.10(Predicted)
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颜色:
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off-white
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稳定性:
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Light Sensitive
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L-165041性质、用途与生产工艺
L-165041 是一种细胞渗透的 PPARδ 激动剂，对 PPARδ 和 PPARγ 的 Ki 值分别为 6 nM 和 约 730 nM，可以在 NIH-PPARδ 细胞中诱导脂肪细胞分化。
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PPARδ
6 nM (Ki)
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PPARγ
730 nM (Ki)
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L-165041 is a PPARδ agonist, with K
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s of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively. L-165041 (1 or 5 µM) inhibits VEGF-induced endothelial cells (ECs) proliferation and migration. L-165041 negatively affects cell cycle progression in VEGF-activated human umbilical vein ECs (HUVECs). L-165041 (10 µM)inhibits PPARδ-independent, VEGF-induced angiogenesis. PPARδ ligand L-165041 inhibits PDGF-induced rVSMC proliferation and migration. With 1 h of L-165041 pretreatment, PDGF-induced cellular migration is inhibited. L-165041 (10 μM) significantly suppresses S phase transition induced by PDGF.
L-165041 (5 mg/kg/day, i.p.) significantly lowers the formation of lipid droplets in mice. L-165041 markedly reduces the level of both the hepatic cholesterol and triglycerides in mice. L-165041 increases mRNA expression levels of PPARδ compared to the vehicle group. Lipoprotein lipase (LPL) expression in L-165041-treated mice is significantly higher than that in the vehicle group.
L-165041
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-20019 | L-165041
L-165041 | 79558-09-1 | 5mg | 604元 |
| 2024/01/25 | HY-20019 | L-165041
L-165041 | 79558-09-1 | 10mM * 1mLin DMSO | 664元 |
79558-09-1, L-165041 相关搜索:
- API
- Intracellular receptor
- 医药中间体
- 细胞生物学
- PPAR and RXR Regulators
- Gene Regulation and Expression
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- C22H26O7
- 2-(4-(3-(4-乙酰基-3-羟基-2-丙基苯氧基)丙氧基)苯氧基)乙酸
- L-165,041 CALBIOCHEM
- [4-[3-(4-乙酰基-3-羟基-2-丙基苯氧基)丙氧基]苯氧基]乙酸
- 79558-09-1
- 100877
- L-165,041 - CAS 79558-09-1 - Calbiochem
- CS-760
- L165041; L 165041
- 4-[3-(2-PROPYL-3-HYDROXY-4-ACETYL)PHENOXY]PROPYLOXYPHENOXY-ACETIC ACID
- 4-[3-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY)PROPOXY]PHENOXYACETIC ACID
- L-165,041
- COMPOUND P
- L 1q5041
- Acetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-
- 2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acid
- 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-
- L-165041, >=98%