H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH
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- CAS号:
- 178249-42-8
- 英文名:
- NOCICEPTIN (1-7)
- 英文别名:
- NOCICEPTIN (1-7);Nociceptin Fragment 1-7;Orphanin FQ Fragment 1-7;L-Alanine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-
- 中文名:
- H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH
- 中文别名:
- 活性代谢多肽NOCICEPTIN (1-7);H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH;L-苯丙氨酰甘氨酰甘氨酰-L-苯丙氨酰-L-苏氨酰甘氨酰-L-丙氨酸
- CBNumber:
- CB5458365
- 分子式:
- C31H41N7O9
- 分子量:
- 655.7
- MOL File:
- Mol file
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H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH化学性质
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沸点:
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1193.6±65.0 °C(Predicted)
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密度:
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1.319±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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形态:
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Powder
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酸度系数(pKa):
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3.42±0.10(Predicted)
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水溶解性:
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Soluble to 2 mg/ml in water
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H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH性质、用途与生产工艺
Nociceptin(1-7) 是 Nociceptin (HY-P0183) 的 N 端生物活性片段。Nociceptin(1-7) 是一种有效的 ORL1 (NOP) 受体激动剂，具有镇痛活性。Nociceptin (1-7) 联合 Nociceptin 可降低体内对痛觉的敏感。
Nociceptin (1-7) (intrathecal injection; 150–1200 nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced.
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Animal Model:
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Mice
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Dosage:
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150–1200 nmol
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Administration:
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Intrathecal injection; single dose
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Result:
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Co-treatment with nociceptin could reduce hyperalgesia.
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H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH
上下游产品信息
上游原料
下游产品
H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH
生产厂家
178249-42-8, H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH 相关搜索:
- Opioid receptor and opioid-like receptor
- 药靶配体
- 目录肽
- C31H41N7O9
- L-苯丙氨酰甘氨酰甘氨酰-L-苯丙氨酰-L-苏氨酰甘氨酰-L-丙氨酸
- 活性代谢多肽NOCICEPTIN (1-7)
- H-PHE-GLY-GLY-PHE-THR-GLY-ALA-OH
- 178249-42-8
- L-Alanine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-
- Orphanin FQ Fragment 1-7
- Nociceptin Fragment 1-7
- NOCICEPTIN (1-7)