Sparstolonin B
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- CAS号:
- 1259330-61-4
- 英文名:
- Sparstolonin B
- 英文别名:
- Sparstolonin B;Sparstolonin B (SsnB);Sparstolonin B >=98% (HPLC);3H-Pyrano[3,4,5-kl]xanthen-3-one, 4,10-dihydroxy-
- 中文名:
- Sparstolonin B
- 中文别名:
- 三棱内酯B
- CBNumber:
- CB54670606
- 分子式:
- C15H8O5
- 分子量:
- 268.22
- MOL File:
- 1259330-61-4.mol
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Sparstolonin B化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO : 10 mg/mL (Need ultrasonic and warming)
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形态:
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powder
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颜色:
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white to beige
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Sparstolonin B性质、用途与生产工艺
Sparstolonin B 作为选择性 TLR2 和 TLR4 拮抗剂，选择性阻断 TLR2 和 TLR4 介导的炎症信号传导。Sparstolonin B 具有抗 HIV 和抗癌活性。
Sparstolonin B (1-20 µM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells.
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2.
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells.
Cell Viability Assay
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Cell Line:
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SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells
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Concentration:
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1 µM, 5 µM, 10 µM or 20 µM
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Incubation Time:
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2-4 days
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Result:
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Effectively and dose-dependently inhibits the viability of all neuroblastoma cell lines after 2 days (SH-SY5Y and IMR-32), 3 days (NGP cells) or 4 days (SKNF-1 and SK-N-BE(2) cells) treatment.
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Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.
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Animal Model:
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5-6-week-old male C57Bl/6 mice (body weight 18-20 g)
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Dosage:
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100 μg/mouse
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Administration:
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I.p.
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Result:
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Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.
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Sparstolonin B
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-116213 | Sparstolonin B | | 1 mg | 954元 |
| 2024/01/25 | HY-116213 | Sparstolonin B
Sparstolonin B | 1259330-61-4 | 5mg | 2100元 |
1259330-61-4, Sparstolonin B 相关搜索:
- 三棱内酯B
- 1259330-61-4
- Sparstolonin B (SsnB)
- Sparstolonin B >=98% (HPLC)
- 3H-Pyrano[3,4,5-kl]xanthen-3-one, 4,10-dihydroxy-
- Sparstolonin B