REVERSINE
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- CAS号:
- 656820-32-5
- 英文名:
- REVERSINE
- 英文别名:
- CS-870;REVERSINE;Reversine, >96%;Reversine, >=98%;REVERSINE USP/EP/BP;Picropodophyllin (PPP);2-(4-MORPHOLINOANILINO)-6-CYCLOHEXYLAMINOPURINE;N6-CYCLOHEXYL-N2-(4-MORPHOLINOPHENYL)-9H-PURINE-2,6-DIAMINE;N6-Cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine;N6-CYCLOHEXYL-N2-[4-(4-MORPHOLINYL)PHENYL]-1H-PURINE-2,6-DIAMINE
- 中文名:
- REVERSINE
- 中文别名:
- 逆转素;逆转素, >96%;AURORA激酶抑制剂(REVERSINE);逆转素(ADENOSINE RECEPTOR拮抗剂);N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺
- CBNumber:
- CB5470820
- 分子式:
- C21H27N7O
- 分子量:
- 393.49
- MOL File:
- 656820-32-5.mol
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REVERSINE化学性质
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熔点:
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305℃ (decomposition)
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沸点:
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736.4±70.0 °C(Predicted)
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密度:
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1.343±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 7 mg/mL, soluble
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形态:
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solid
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酸度系数(pKa):
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10.51±0.10(Predicted)
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颜色:
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Off-white
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
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REVERSINE性质、用途与生产工艺
Reversine是一种强效human A3 adenosine receptor拮抗剂，K
i为0.66 μM，也是一种泛aurora A/B/C kinase抑制剂，IC50分别为12 nM/13 nM/20 nM。也用于干细胞分化。
Reversine induces myogenic lineage-committed cells to become multipotent mesenchymal progenitor cells, which proliferates and redifferentiates into bone and fat cells. Reversine, as an A3 adenosine receptor antagonist, competitively inhibits forskolin-stimulated cAMP production in stably transfected Chinese hamster ovary (CHO) cells. Reversine inhibits the phosphorylation of a well-known Aurora target, histone H3 in HCT116 cells. Moreover, Reversine potently blocks proliferation of multiple tumor cell types, and induces cell death. In primary human tumor samples, Reversine also inhibits colony formation of leukemic cells. When treated in combination, reversine and aspirin synergistically inhibit growth of cervical cancer cells and induce cell apoptosis.
In mice inoculated with U14 tumors, Reversine (10 mg/kg i.p.) and aspirin cause more reduced tumor weight and tumor volume when compared with the control agents.
REVERSINE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14711 | Reversine | | 1 mg | 295元 |
| 2024/01/25 | HY-14711 | REVERSINE
Reversine | 656820-32-5 | 5mg | 651元 |
656820-32-5, REVERSINE 相关搜索:
- Inhibitors
- 药靶配体
- 试剂盒-细胞分析试剂盒
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- C21H27N7O
- 逆转素(ADENOSINE RECEPTOR拮抗剂)
- N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺
- AURORA激酶抑制剂(REVERSINE)
- 逆转素, >96%
- 逆转素
- 656820-32-5
- Reversine, >96%
- REVERSINE USP/EP/BP
- CS-870
- Reversine, >=98%
- N6-CYCLOHEXYL-N2-[4-(4-MORPHOLINYL)PHENYL]-1H-PURINE-2,6-DIAMINE
- REVERSINE
- Reversine
N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine
- N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine Reversine
- Picropodophyllin (PPP)
- N6-CYCLOHEXYL-N2-(4-MORPHOLINOPHENYL)-9H-PURINE-2,6-DIAMINE
- 2-(4-MORPHOLINOANILINO)-6-CYCLOHEXYLAMINOPURINE
- N6-Cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine
- 9H-Purine-2,6-diamine,N6-cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-