二甲苯氧庚酸-Β-D-葡糖苷酸
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- CAS号:
- 91683-38-4
- 英文名:
- GEMFIBROZIL 1-O--GLUCURONIDE
- 英文别名:
- Gemfibrozil Impurity 12;Gemfibrozil Impurity 13;Gemfibrozilb-D-glucuronide;Gemfibrozil-β-D-glucuronide;Gemfibrozil 1-O-b-Glucuronide;GEMFIBROZIL 1-O-?-GLUCURONIDE;Gemfibrozil 1-O-β-Glucuronide;gemfibrozil 1-O-acylglucuronide;Gemfibrozil-β-O-β-D-Glucuronide;Gemfibrozil-β-O-β-D-Glucuronide
- 中文名:
- 二甲苯氧庚酸-Β-D-葡糖苷酸
- 中文别名:
- 吉非罗齐杂质12;吉非罗齐杂质10;吉非罗齐杂质13;吉非罗齐1-O葡萄糖醛酸苷;吉非罗齐1-O-Β-葡糖苷酸;二甲苯氧庚酸-Β-D-葡糖苷酸;吉非贝齐 1-O-酰基葡糖苷酸;二甲苯氧庚酸-Β-D-葡糖苷酸;吉非罗齐酰基-Β-D-葡萄糖醛酸;吉非贝齐酰基 - Β-D葡糖苷酸
- CBNumber:
- CB5506729
- 分子式:
- C21H30O9
- 分子量:
- 426.46
- MOL File:
- 91683-38-4.mol
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二甲苯氧庚酸-Β-D-葡糖苷酸化学性质
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熔点:
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>103°C (dec.)
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沸点:
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611.2±55.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Hygroscopic, -20°C Freezer, Under Inert Atmosphere
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溶解度:
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Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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2.68±0.70(Predicted)
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颜色:
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White to Off-White
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稳定性:
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Very Hygroscopic
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二甲苯氧庚酸-Β-D-葡糖苷酸性质、用途与生产工艺
Gemfibrozil 1-O-β-Glucuronide 是 Gemfibrozil (CI-719; HY-B0258) 的代谢产物，是一种有效且竞争性的 P450 (CYP) 亚型 CYP2C8 抑制剂，IC50 为 4.07 μM。
Gemfibrozil 1-O-β-Glucuronide significantly inhibits the OATP2 (OATP1B1)-mediated uptake of Cerivastatin (CER; HY-129458) with an IC
50
of 24.3 μM.
Gemfibrozil 1-O-β-Glucuronide inhibits CYP2C8-mediated M1, M23 formation with IC
50
s of 5.38 μM, 4.30 μM, and has no effects for CYP2C8-mediated M3 formation.
Gemfibrozil 1-O-β-Glucuronide has an IC
50
of 243 μM for the CYP3A4- mediated metabolism.
二甲苯氧庚酸-Β-D-葡糖苷酸
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-129993 | 二甲苯氧庚酸-Β-D-葡糖苷酸
Gemfibrozil 1-O-β-glucuronide | 91683-38-4 | 1 mg | 2800元 |
| 2024/01/25 | HY-129993 | 二甲苯氧庚酸-Β-D-葡糖苷酸
Gemfibrozil 1-O-β-glucuronide | 91683-38-4 | 5 mg | 9500元 |
91683-38-4, 二甲苯氧庚酸-Β-D-葡糖苷酸 相关搜索:
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Inhibitors
- Glucuronides
- 抑制剂
- 吉非贝齐酰基-Β-D-葡萄糖苷酸
- 吉非罗齐1-O-Β-葡糖苷酸
- 吉非罗齐酰基-Β-D-葡萄糖醛酸
- 二甲苯氧庚酸-Β-D-葡糖苷酸
- 吉非罗齐杂质12
- 吉非罗齐杂质10
- 吉非罗齐杂质13
- 吉非贝齐 1-O-酰基葡糖苷酸
- 吉非贝齐酰基 - Β-D葡糖苷酸
- 二甲苯氧庚酸-Β-O-Β-D-葡糖苷酸[干冰运输]
- 吉非罗齐1-O葡萄糖醛酸苷
- 二甲苯氧庚酸-Β-D-葡糖苷酸
- 91683-38-4
- Gemfibrozil acyl-b-D-glucuronide
- Gemfibrozil Impurity 13
- Gemfibrozil-β-O-β-D-Glucuronide D6
- Gemfibrozil-β-O-β-D-Glucuronide
- Gemfibrozil 1-O-β-Glucuronide (contains up to 15% α isomer)
DISCONTINUED. Please see G305755.
- Gemfibrozil acyl-β-D-glucuronide
- Gemfibrozil 1-O-β-Glucuronide
- Gemfibrozil Impurity 12
- β-D-Glucopyranuronic acid, 1-[5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate]
- Gemfibrozil-acyl-β-D-glucuronide
- Gemfibrozil-β-O-β-D-Glucuronide
- Gemfibrozil 1-O-β-Glucuronide (contains up to 15% α isomer)
- Gemfibrozil-β-D-glucuronide
- GeMfibrozil Acyl-beta-D-Glucuronide
- Gemfibrozil-acyl-beta-D-glucuronide min. 95%
- Gemfibrozil b-D-glucuronide ,98%
- beta-D-Glucopyranuronic acid, 1-(5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoate)
- 1-o-Gemfibrozil-beta-D-glucuronide
- 1-[5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoate] -D-Glucopyranuroic Acid
- gemfibrozil 1-O-acylglucuronide
- Gemfibrozilb-D-glucuronide
- Gemfibrozil 1-O-b-Glucuronide
- 1-[5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoate] b-D-Glucopyranuroic Acid, Gemfibrozil Glucuronide
- GEMFIBROZIL 1-O-?-GLUCURONIDE