Colivelin TFA
|
|
|
- CAS号:
- 英文名:
- Colivelin TFA
- 英文别名:
- Colivelin TFA
- 中文名:
- Colivelin TFA
- 中文别名:
- CBNumber:
- CB55419714
- 分子式:
- C???H???N??O??.C?HF?O?
- 分子量:
- 0
- MOL File:
- Mol file
|
|
|
Colivelin TFA性质、用途与生产工艺
Colivelin TFA 是一种具有大脑通透性的神经保护肽 (neuroprotective peptide)，是 STAT3 的有效激活剂。Coliveli 通过激活 STAT3 在体外抑制神经元死亡。Colivelin TFA 对神经毒性、Aβ 沉积,神经元细胞凋亡，在神经退行性疾病显示出长期有利的影响。Colivelin TFA 可用于阿尔茨海默病和缺血性脑损伤的相关研究。
Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Aβ1-43 at a concentration of 100 fm, and keep its neuroprotective action at or above the levels of 1 nm.Colivelin-induced neuroprotection occurs via two neuroprotective pathways: one mediated by Ca
2+
/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN.
Colivelin reverses caspase3, Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition.
Colivelin (50 µg/mL, 4 hours) significantly increases the p-STAT3 protein levels in BV-2 cells.
Western Blot Analysis
|
Cell Line:
|
BV-2 cells.
|
|
Concentration:
|
50 µg/mL.
|
|
Incubation Time:
|
4 hours.
|
|
Result:
|
Increased p-STAT3 levels.
|
Cell Viability Assay
|
Cell Line:
|
KYSE70 and TE8 cells.
|
|
Concentration:
|
0.5 μM.
|
|
Incubation Time:
|
1 hour (followed by CYT-Rx20 treatment)
|
|
Result:
|
Significantly suppressed the viability in KYSE70 and TE8 cells.
|
Colivelin(intracerebroventricular administration; 10 pmol/3 μl; 3 weeks) suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, in addition, it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42.
Colivelin (intraperitoneal administration; 1.4, 7, or 35 nM/0.21mL; on the Y-maze testday) suppresses memory impairment caused by 3-quinuclidinyl benzilateand restricts functional memory deficit.
Colivelin (intraperitoneal injection; 1 mg/kg; 14 days) results in improved motor and cognitive function with time by performance of mNSS, rotarod, and corner turning test.It also reduces lesion volume and improves neurological deficits after MCAO.
|
Animal Model:
|
CD-1 mice
|
|
Dosage:
|
10 pmol/3 μl
|
|
Administration:
|
Intracerebroventricular administration
|
|
Result:
|
Completely suppressed Aβ 25-35-mediated impairment in spatial working memory and increased the number of immunoreactive neurons.
|
|
Animal Model:
|
C57 mice
|
|
Dosage:
|
1.4, 7, or 35 nM/0.21mL
|
|
Administration:
|
Intraperitoneal administration
|
|
Result:
|
Protected against cholinotoxin-induced amnesia in mice.
|
|
Animal Model:
|
Male C57BL/6 mice
|
|
Dosage:
|
1 mg/kg
|
|
Administration:
|
Intraperitoneal administration
|
|
Result:
|
Protected against ischemic brain injury, and improves neurological outcomes.
|
Colivelin TFA
上下游产品信息
上游原料
下游产品
Colivelin TFA 试剂级价格
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-P1061A | Colivelin TFA
Colivelin TFA | | 1mg | 3480元 |
| 2024/04/30 | HY-P1061A | Colivelin TFA
Colivelin TFA | | 5 mg | 9750元 |