PS372424
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- CAS号:
- 914291-61-5
- 英文名:
- PS372424
- 英文别名:
- PS372424;PS372424,PS-372424;3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[(cyclohexylmethyl)amino]carbonyl]butyl]-2-(1,4-dioxo-4-phenylbutyl)-1,2,3,4-tetrahydro-, (3S)-
- 中文名:
- PS372424
- 中文别名:
- 化合物 T12567
- CBNumber:
- CB55419820
- 分子式:
- C??H??N?O?
- 分子量:
- 588.74
- MOL File:
- 914291-61-5.mol
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PS372424化学性质
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密度:
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1.29±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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13.47±0.20(Predicted)
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PS372424性质、用途与生产工艺
PS372424，CXCL10 的三个氨基酸片段，是一种特异的人 CXCR3 激动剂，具有抗炎活性。在关节炎炎症模型中，PS372424 可抑制 T 细胞迁移。
PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation.
PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3
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T cells not in CXCR3
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T cells.
PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC
50
of 42±21 nM.
Western Blot Analysis
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Cell Line:
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CXCR3
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T cells and CXCR3
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T cells
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Concentration:
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10, 50, 100, or 200 nM
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Incubation Time:
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30 minutes
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Result:
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Caused a concentration-dependent phosphorylation of CCR5 on CXCR3
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T cells. Did not result in phosphorylation of CCR5 on CXCR3
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T cells.
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PS372424
上下游产品信息
上游原料
下游产品
914291-61-5, PS372424 相关搜索:
- C33H44N6O4
- 化合物 T12567
- 914291-61-5
- PS372424,PS-372424
- 3-Isoquinolinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[(cyclohexylmethyl)amino]carbonyl]butyl]-2-(1,4-dioxo-4-phenylbutyl)-1,2,3,4-tetrahydro-, (3S)-
- PS372424