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4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇
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- CAS号:
- 1202764-53-1
- 英文名:
- 4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol
- 英文别名:
- B022;B022,B-022;4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol;2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl-
- 中文名:
- 4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇
- 中文别名:
- B022;化合物 T14491;4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇
- CBNumber:
- CB55582861
- 分子式:
- C19H16ClN5OS
- 分子量:
- 397.88
- MOL File:
- 1202764-53-1.mol
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4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇化学性质
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沸点:
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644.4±65.0 °C(Predicted)
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密度:
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1.53±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (628.33 mM)
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酸度系数(pKa):
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10.71±0.29(Predicted)
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4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇性质、用途与生产工艺
B022 是一种有效的选择性的 NF-κB 诱导激酶 (NIK) 抑制剂，Ki 为 4.2 nM。B022 可保护肝脏免受毒素引起的炎症，氧化应激和伤害。
Ki: 4.2 nM (NF-κB-inducing kinase (NIK))
B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner.
B022 (0-5 μM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.
Western Blot Analysis
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Cell Line:
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Hepa1 cells
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Concentration:
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0 μM, 0.5 μM, 5 μM
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Incubation Time:
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12 hours
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Result:
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Suppressed NIK-induced p52 formation in a dose-dependent manner.
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RT-PCR
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Cell Line:
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Hepa1 cells
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Concentration:
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0 μM, 0.5 μM, 5 μM
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Incubation Time:
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12 hours
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Result:
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Dose-dependently blocked NIK-induced expression of chemokines, cytokines, and iNOS in these cells. Completely blocked NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.
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B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses.
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Animal Model:
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STOP-NIK male mice (8 weeks) infected with Ad-cre
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Dosage:
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30 mg/kg
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Administration:
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Intravenous injection; twice a day; for 10 days
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Result:
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Completely prevents the lethal effect of abnormally high levels of hepatic NIK in mice. Inhibited the majority of the deteriorating effects of aberrant activation of hepatic NIK.
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4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-120501 | B022 | | 1 mg | 931元 |
| 2024/01/25 | HY-120501 | 4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇
B022 | 1202764-53-1 | 5mg | 2050元 |
4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇
生产厂家
1202764-53-1, 4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇 相关搜索:
- 活性分子
- 化合物 T14491
- B022
- 4-(1-(2-氨基-5-氯嘧啶-4-基)-2-(噻唑-2-基)-3-丁炔-2-醇
- 1202764-53-1
- B022,B-022
- 2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl-
- B022
- 4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol