1-苯基双胍
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- CAS号:
- 102-02-3
- 英文名:
- PHENYLBIGUANIDE
- 英文别名:
- p1426;PHENYLBIGUANIDE;phenyldiguanide;phenyl-biguanid;1-PHENYLBIGUANIDE;1-phenyl-biguanid;N-Phenylbiguanide;Phenylbiguanide>n-phenyl-n’-guanylguanidine;2-(N2-Phenylamidino)guanidine
- 中文名:
- 1-苯基双胍
- 中文别名:
- 苯基双胍;1-苯基双胍
- CBNumber:
- CB5676800
- 分子式:
- C8H11N5
- 分子量:
- 177.21
- MOL File:
- 102-02-3.mol
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1-苯基双胍化学性质
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熔点:
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135-142 °C (lit.)
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沸点:
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299.13°C (rough estimate)
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密度:
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1.2512 (rough estimate)
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折射率:
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1.6900 (estimate)
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储存条件:
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Keep in dark place,Sealed in dry,Room Temperature
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溶解度:
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alcohol: freely soluble
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酸度系数(pKa):
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10.76, 2.13(at 25℃)
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形态:
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powder to crystal
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颜色:
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White to Orange to Green
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Merck:
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14,7276
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InChIKey:
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CUQCMXFWIMOWRP-UHFFFAOYSA-N
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CAS 数据库:
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102-02-3(CAS DataBase Reference)
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1-苯基双胍性质、用途与生产工艺
1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide)是一种 5-hydroxytryptamine3 (5-HT3) receptor 激动剂，EC50为3.0 μM。
| Target | Value |
5-HT3 receptor
(Cell-free assay)
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3.0 μM(EC50)
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Phenylbiguanide (1-Phenylbiguanide) is a 5-HT
3
receptor selective agonist with pEC
50
s of 5.57, 4.07, and 4.47 for r5-HT
3A(b)
, h5-HT
3A
, m5-HT
3A(b)
, respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).
In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.
1-苯基双胍
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101331 | 1-苯基双胍
Phenylbiguanide | 102-02-3 | 100mg | 990元 |
| 2024/01/25 | HY-101331 | 1-苯基双胍
Phenylbiguanide | 102-02-3 | 10mM * 1mLin DMSO | 1089元 |
1-苯基双胍
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102-02-3, 1-苯基双胍 相关搜索:
- Serotonergics
- Nitrogen Compounds
- Neurotransmitters
- Guanidines
- AgonistsOrganic Building Blocks
- 高端化学
- 有机化学
- 胍
- Nitrogen Compounds
- Organic Building Blocks
- Guanidines
- Building Blocks
- C6H5NHCNHNHCNHNH2
- C6H5NHCNHNHCNH
- C8H11N5
- 1-苯基双胍
- 苯基双胍
- 102-02-3
- 5-hydroxytryptamine Receptor,Phenylbiguanide,inhibit,Serotonin Receptor,Inhibitor,5-HT Receptor
- Imidodicarbonimidic diamide, N-phenyl-
- N-Phenylbiguanide
- Phenylbiguanide>
- Phenylbiguanide (N-Phenylbiguanide
- Phenylbiguanide (Synonyms: N-Phenylbiguanide
- n-phenyl-n’-guanylguanidine
- 1-phenyl-biguanid
- 2-(N2-Phenylamidino)guanidine
- PHENYLBIGUANIDE
- N-PHENYLIMINODICARBONIMIDIC-DIAMIDE
- 1-PHENYLBIGUANIDE
- phenyldiguanide
- phenyl-biguanid
- p1426