HOECHST 34580
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- CAS号:
- 23555-00-2
- 英文名:
- HOECHST 34580
- 英文别名:
- ProaMine;HOE 34580;HOECHST 34580;Hoechst 34580 (HOE 34580);2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
- 中文名:
- HOECHST 34580
- 中文别名:
- 赫斯特34580游离;NO34580 荧光染料;化合物HOECHST 34580;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯胺;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯胺
- CBNumber:
- CB5729663
- 分子式:
- C27H29N7
- 分子量:
- 451.57
- MOL File:
- 23555-00-2.mol
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HOECHST 34580化学性质
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熔点:
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>300℃
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沸点:
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733.2±70.0 °C(Predicted)
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密度:
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1.280±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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Soluble in dimethyl sulfoxide, water
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形态:
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powder
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酸度系数(pKa):
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10.97±0.10, most acidic, temperature:
25 °C; 7.66 ± 0.42, most basic(at 25℃)
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颜色:
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Yellow to green
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最大波长(λmax):
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392nm
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生物领域应用:
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Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing
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HOECHST 34580性质、用途与生产工艺
Hoechst 34580 (HOE 34580) 是一种具有细胞渗透性的蓝色荧光染料，用于染色DNA和细胞核。Hoechst 34580 也是一种治疗阿尔茨海默病的良好候选者，通过抑制 amyloid beta (Aβ) 的形成，其IC50值为0.86 μM。
| Target | Value |
Aβ
(Cell-free assay)
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0.86 μM
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Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC
50
of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC
50
) is examined. The IC
50
is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.
HOECHST 34580
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | S0486 | HOECHST 34580
Hoechst 34580 | 23555-00-2 | 5mg | 2047.06元 |
| 2024/01/16 | S0486 | HOECHST 34580
Hoechst 34580 | 23555-00-2 | 25mg | 6445.63元 |
23555-00-2, HOECHST 34580 相关搜索:
- Benzimidazole
- 药靶配体
- C27H29N7
- C27H32Cl3N7
- N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯胺
- NO34580 荧光染料
- 化合物HOECHST 34580
- N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯胺
- 赫斯特34580游离
- 23555-00-2
- N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
- N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
- Hoechst 34580 (HOE 34580)
- Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-
- 2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-
- ProaMine
- HOE 34580
- HOECHST 34580