非达司他
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- CAS号:
- 136087-85-9
- 英文名:
- Fidarestat
- 英文别名:
- Aldos;Sk 860;CS-489;SNK-860;fidarestat;Fidarestat
(SNK-860;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione;(2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide;(2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide
- 中文名:
- 非达司他
- 中文别名:
- 非达司他;化合物 T15281;(2S,4S)-6-氟-2',5'-二氧代-螺[色满-4,4'-咪唑啉]-2-甲酰胺;(2S,4S)-2-氨基甲酰-6-氟-螺[苯并二氢吡喃-4,4'-咪唑啉]-2',5'-酮
- CBNumber:
- CB5855234
- 分子式:
- C12H10FN3O4
- 分子量:
- 279.22
- MOL File:
- 136087-85-9.mol
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非达司他化学性质
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密度:
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1.61±0.1 g/cm3(Predicted)
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溶解度:
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DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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8.46±0.40(Predicted)
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非达司他性质、用途与生产工艺
Fidarestat (SNK 860) 是一种醛糖还原酶 (aldose reductase) 抑制剂,对 aldose reductase,AKR1B10 和 V301L AKR1B10 的 IC50 值分别为 26 nM,33 μM 和 1.8 μM。Fidarestat (SNK 860) 具有研究糖尿病的潜力。
IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)
Fidarestat is an inhibitor of aldose reductase, with IC
50
s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively.
Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats.
非达司他
上下游产品信息
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-105185 | 非达司他 Fidarestat | 136087-85-9 | 1 mg | 630元 |
2024/01/25 | HY-105185 | 非达司他 Fidarestat | 136087-85-9 | 5mg | 1800元 |
136087-85-9, 非达司他 相关搜索:
- 化合物 T15281
- (2S,4S)-6-氟-2',5'-二氧代-螺[色满-4,4'-咪唑啉]-2-甲酰胺
- 非达司他
- (2S,4S)-2-氨基甲酰-6-氟-螺[苯并二氢吡喃-4,4'-咪唑啉]-2',5'-酮
- 136087-85-9
- FidarestatQ: What is
Fidarestat Q: What is the CAS Number of
Fidarestat Q: What is the storage condition of
Fidarestat Q: What are the applications of
Fidarestat
- Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S,4S)-
- CS-489
- Fidarestat
(SNK-860
- Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S-cis)-
- Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 2,3-dihydro-2',5'-dioxo-6-fluoro-, (2S-cis)-
- Sk 860
- Aldos
- SNK-860
- (2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide
- (2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide
- (2S,4S)-6-FLUORO-2'',5''-DIOXOSPIRO(3,4-DIHYDRO-2H-1-BENZOPYRAN-4,4''-IMIDAZOLIDINE)-2-CARBOXAMIDE
- fidarestat
- (2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione
- (2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide