CS-2701
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- CAS号:
- 289483-69-8
- 英文名:
- E-7820
- 英文别名:
- E-7820;CS-2701;ER 68203-00;E 7820; E-7820;ER68203-00;E7820;E-7820;E 7820;289483-69-8;3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide;N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide;Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-;E7820,cell,tumor,WiDr,derivative,Integrin,colorectal,LoVo,inhibit,Inhibitor,sulfonamide,HUVEC,endothelium,E 7820,E-7820;3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239
- 中文名:
- CS-2701
- 中文别名:
- 化合物E7820;血管生成抑制剂(E7820);E 7820,Α2整合素抑制剂;3-氰基-N-(3-氰基-4-甲基-1H-吲哚-7-基)苯磺酰胺
- CBNumber:
- CB61011214
- 分子式:
- C17H12N4O2S
- 分子量:
- 336.37
- MOL File:
- 289483-69-8.mol
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CS-2701化学性质
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沸点:
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626.2±65.0 °C(Predicted)
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密度:
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1.48±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:67.0(Max Conc. mg/mL);199.19(Max Conc. mM)
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形态:
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A crystalline solid
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酸度系数(pKa):
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8.17±0.30(Predicted)
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CS-2701性质、用途与生产工艺
E7820是独特的血管生成抑制剂，具有抗肿瘤活性。
E7820 (ER68203-00) inhibits both bFGF- and VEGF-driven ube formation of human umbilical vascular endothelial cell (HUVEC) in a dose-dependent manner with IC
50
of 0.20 and 0.24 μg/ml, respectively.
E7820 inhibits proliferation of HUVEC induced by either bFGF or VEGF in serum-free medium (SFM). The IC
50
values are 0.10 and 0.081 μg/ml, respectively. Antiproliferative activity of E7820 against both WiDr and LoVo cells is very weak compared with that against HUVEC. The values of IC50 were 29 and 15 μg/ml, respectively.
E7820 (ER68203-00) (50-200 mg/kg; p.o. ; twice daily for 14 days) delays the growth of WiDr cells inoculated s.c..
E7820 (200-400 mg/kg; p.o.;once daily for 4 days) potently inhibits WiDr-induced angiogenesis.
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Animal Model:
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Six-week-old female nude mice (KSN mice, WiDr-induced angiogenesis model)
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Dosage:
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50, 100, 200 mg/kg
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Administration:
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p.o. ; twice daily for 14 days from 2 days after inoculation of the tumor cells
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Result:
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The antitumor effect was dose-dependent at 50, 100, and 200 mg/kg, and the tumor growth rates were 52%, 46%, and 27%, respectively.
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CS-2701
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14571 | E7820 | | 1 mg | 431元 |
| 2024/01/25 | HY-14571 | CS-2701
E7820 | 289483-69-8 | 5mg | 950元 |
289483-69-8, CS-2701 相关搜索:
- 药靶配体
- 化工试剂
- 药物活性分子
- 细胞生物学试剂
- E 7820,Α2整合素抑制剂
- 3-氰基-N-(3-氰基-4-甲基-1H-吲哚-7-基)苯磺酰胺
- 血管生成抑制剂(E7820)
- 化合物E7820
- 289483-69-8
- 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239
- E7820,cell,tumor,WiDr,derivative,Integrin,colorectal,LoVo,inhibit,Inhibitor,sulfonamide,HUVEC,endothelium,E 7820,E-7820
- Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-
- ER68203-00;E7820;E-7820;E 7820;289483-69-8
- CS-2701
- E 7820; E-7820
- N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide
- 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
- ER 68203-00
- E-7820