氨磷汀硫化物
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- CAS号:
- 31098-42-7
- 英文名:
- 2-(3-aminopropylamino)ethanethiol
- 英文别名:
- WR 1065;Demeton Impurity 5;2-(3-aminopropylamino)ethanethiol;Ethanethiol,2-[(3-aminopropyl)amino]-;N-(2-Mercaptoethyl)-1,3-propanediamine;2-((3-Aminopropyl)amino)ethyl hydrosulfide
- 中文名:
- 氨磷汀硫化物
- 中文别名:
- 氨磷汀硫化物
- CBNumber:
- CB61255898
- 分子式:
- C5H14N2S
- 分子量:
- 134.24
- MOL File:
- 31098-42-7.mol
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氨磷汀硫化物化学性质
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沸点:
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218.6±15.0 °C(Predicted)
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密度:
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0.975±0.06 g/cm3(Predicted)
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储存条件:
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4°C, protect from light, stored under nitrogen
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溶解度:
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DMSO: < 1 mg/mL (insoluble or slightly soluble)
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酸度系数(pKa):
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10.00±0.10(Predicted)
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形态:
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Solid
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颜色:
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White
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水溶解性:
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Water: 250 mg/mL (1862.34 mM)
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氨磷汀硫化物性质、用途与生产工艺
Amifostine thiol (WR-1065) 是细胞保护剂 Amifostine (HY-B0639) 的活性代谢物。Amifostine thiol 是一种具有辐射防护能力的细胞保护剂。Amifostine thiol 通过 JNK 依赖的信号通路激活 p53。
Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures.
Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation.
Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation.
Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability.
Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment.
Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage.
Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81.
Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.
氨磷汀硫化物
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31098-42-7, 氨磷汀硫化物 相关搜索:
- C5H14N2S
- 氨磷汀硫化物
- 31098-42-7
- Demeton Impurity 5
- Ethanethiol,2-[(3-aminopropyl)amino]-
- 2-((3-Aminopropyl)amino)ethyl hydrosulfide
- N-(2-Mercaptoethyl)-1,3-propanediamine
- WR 1065
- 2-(3-aminopropylamino)ethanethiol