伊罗替罗
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- CAS号:
- 355129-15-6
- 英文名:
- Eprotirome
- 英文别名:
- Kb-2115;eprotirome;Unii-958aq7B6R1;Eprotirome(KB-2115);KB2115 Exclusive;VPCSYAVXDAUHLT-UHFFFAOYSA-N;N-[3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid;THR,inhibit,KB 2115,Eprotirome,Inhibitor,KB-2115,Thyroid Hormone Receptor;3-((3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl)amino)-3-oxopropanoic acid;3-((3,5-Dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid
- 中文名:
- 伊罗替罗
- 中文别名:
- 伊罗替罗;N-[3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基]丙酰胺酸;3-((3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基)氨基)-3-氧丙酸;3-((3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基)氨基)-3-氧代丙酸
- CBNumber:
- CB61518511
- 分子式:
- C18H17Br2NO5
- 分子量:
- 487.14
- MOL File:
- 355129-15-6.mol
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伊罗替罗化学性质
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沸点:
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596.3±50.0 °C(Predicted)
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密度:
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1.708
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO:84.0(Max Conc. mg/mL);172.43(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);61.58(Max Conc. mM)
Ethanol:63.5(Max Conc. mg/mL);130.35(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.03(Max Conc. mM)-
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形态:
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A crystalline solid
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酸度系数(pKa):
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3.16±0.32(Predicted)
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伊罗替罗性质、用途与生产工艺
Eprotirome (KB2115) 是肝脏选择性甲状腺激素受体 (thyroid hormone receptor, TR) 激动剂。KB2115 对 TRβ 的亲和力略高于 TRα。Eprotirome 降低了低密度脂蛋白 (LDL) 胆固醇的浓度，可用于血脂异常和肥胖症的研究。
Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice.
伊罗替罗
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-10473 | Eprotirome | | 5 mg | 600元 |
| 2024/01/25 | HY-10473 | Eprotirome | | 10 mg | 950元 |
355129-15-6, 伊罗替罗 相关搜索:
- 3-((3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基)氨基)-3-氧代丙酸
- 3-((3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基)氨基)-3-氧丙酸
- 伊罗替罗
- N-[3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基]丙酰胺酸
- 355129-15-6
- Eprotirome(KB-2115)
- THR,inhibit,KB 2115,Eprotirome,Inhibitor,KB-2115,Thyroid Hormone Receptor
- VPCSYAVXDAUHLT-UHFFFAOYSA-N
- KB2115 Exclusive
- 3-((3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl)amino)-3-oxopropanoic acid
- Propanoic acid,3-[[3,5-dibroMo-4-[4-hydroxy-3-(1-Methylethyl)phenoxy]phenyl]aMino]-3-oxo-
- Unii-958aq7B6R1
- Kb-2115
- 3-((3,5-Dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid
- N-[3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid
- eprotirome