(±)-TRANS-ACPD
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- CAS号:
- 67684-64-4
- 英文名:
- (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID
- 英文别名:
- TRANS-ACPD;Trans-(±)-ACP;Trans-(±)-ACP;TRANS-(±)-ACPD;TRANS-(+/-)-ACPD;(+/-)-TRANS-ACPD;trans-(±)-ACPD monohydrate;TRANS(+-)-ACPD EXCITATORY AMINO ACID;trans-1-Aminocyclopentane-1,3-dicarboxylic acid;TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID
- 中文名:
- (±)-TRANS-ACPD
- 中文别名:
- 化合物(±)-TRANS-ACPD;TRANS-1-氨基环戊烷-1,3-二羧酸
- CBNumber:
- CB6198448
- 分子式:
- C7H11NO4
- 分子量:
- 173.17
- MOL File:
- 67684-64-4.mol
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(±)-TRANS-ACPD化学性质
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沸点:
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352.7±42.0 °C(Predicted)
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密度:
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1.452±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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H2O: soluble1mg/mL
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酸度系数(pKa):
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2.11±0.40(Predicted)
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形态:
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solid
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颜色:
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white
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水溶解性:
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Soluble to 5 mM in water with gentle warming and to 50 mM in 1eq. NaOH
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(±)-TRANS-ACPD性质、用途与生产工艺
trans-ACPD 是一种代谢型受体激动剂，促进钙离子活动及产生内向电流。
Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC
50
value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC
50
values are 480-850 μM).
Intrathecal injection of NMDA, kainate, and trans-ACPD, TNF-α, or IL-1β causes significant (p<0.001) biting behaviour in mice compared to animals injected intrathecally with saline. In all groups, systemic pre-treatment with GM (100 mg/kg, i.p.) significantly (p<0.001) reduces the biting behaviour compared to mice treated with saline (10 mL/kg, i.p.). The greatest effect of GM is observed on the pro-inflammatory cytokines and NMDA, with the following inhibition percentages: TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). By contrast, at the same dose, GM has no significant effect on the kainate-mediated biting response.
(±)-TRANS-ACPD
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-19434 | (±)-TRANS-ACPD
trans-ACPD | 67684-64-4 | 2mg | 660元 |
| 2024/01/25 | HY-19434 | (±)-TRANS-ACPD
trans-ACPD | 67684-64-4 | 10mM * 1mLin DMSO | 726元 |
67684-64-4, (±)-TRANS-ACPD 相关搜索:
- C7H11NO4H2O
- TRANS-1-氨基环戊烷-1,3-二羧酸
- 化合物(±)-TRANS-ACPD
- 67684-64-4
- (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID
- trans-ACPD,transACPD,Metabotropic glutamate receptors,trans ACPD,mGluR,Inhibitor,inhibit
- trans-1-Aminocyclopentane-1,3-dicarboxylic acid
- Trans-(±)-ACP
- 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1R,3S)-rel-
- Trans-(±)-ACP
- TRANS-(±)-ACPD
- (+/-)-1-Aminocyclopentanl-trans-1,3-Dicarboxylic acid
- trans-(±)-ACPD monohydrate
- trans-(±)-1-Amino-1,3-cyclopentanedicarboxylic acid monohydrate
- TRANS(+-)-ACPD EXCITATORY AMINO ACID
- TRANS-ACPD
- TRANS-(+/-)-ACPD
- (+/-)-TRANS-ACPD
- TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID
- (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID