化合物 T22044
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- CAS号:
- 17375-63-2
- 英文名:
- 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
- 英文别名:
- BGC 20-761;5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine;1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-2-phenyl-
- 中文名:
- 化合物 T22044
- 中文别名:
- 化合物 T22044
- CBNumber:
- CB62518824
- 分子式:
- C19H22N2O
- 分子量:
- 294.39
- MOL File:
- 17375-63-2.mol
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化合物 T22044化学性质
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沸点:
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489.2±45.0 °C(Predicted)
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密度:
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1.114±0.06 g/cm3(Predicted)
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储存条件:
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Store at +4°C
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溶解度:
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<14.72mg/ml in ethanol; <29.44mg/ml in DMSO
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形态:
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solid
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酸度系数(pKa):
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16.74±0.30(Predicted)
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颜色:
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White
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化合物 T22044性质、用途与生产工艺
BGC20-761 是一种选择性的 5-HT6 和多巴胺受体 (dopamine receptor) 拮抗剂，对人 5-HT6，5-HT2A，D2 受体的 Ki 值分别为 20，69，和 140 nM。BGC20-761 可增强长期记忆。BGC20-761 可用于抗精神病的研究。
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Human 5-HT
6
Receptor
20 nM (Ki)
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Human 5-HT
2A
Receptor
69 nM (Ki)
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Human D
2
Receptor
140 nM (Ki)
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BGC20-761 has highly potent and selective 5-HT6 receptor antagonist activity; rat K
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values for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM).
BGC20-761 enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. BGC20-761 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; i.p.) alone has no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reverses a deficit of social recognition induced by Scopolamine (0.4 mg/kg i.p.).
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Animal Model:
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Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats
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Dosage:
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2.5 mg/kg, 5 mg/kg and 10 mg/kg
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Administration:
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Administered (i.p.) immediately after the training session for the social recognition test
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Result:
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Administered alone did not show any difference in social recognition as compared to saline treated control animals.
However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition.
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化合物 T22044
上下游产品信息
上游原料
下游产品
17375-63-2, 化合物 T22044 相关搜索:
- 化合物 T22044
- 17375-63-2
- 1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-2-phenyl-
- BGC 20-761
- 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine