GNE 477
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- CAS号:
- 1032754-81-6
- 英文名:
- GNE 477
- 英文别名:
- GNE 477;CS-1884;5-(7-Methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-;mTOR,Phosphoinositide 3-kinase,GNE-477,Inhibitor,Mammalian target of Rapamycin,GNE477,inhibit,PI3K;5-(7-Methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine;5-[7-Methyl-4-(Morpholin-4-yl)-6-[(4-Methylsulfonylpiperazin-1-yl)Methyl]thieno[3,2-d]pyriMidin-2-yl]pyriMidin-2-aMine;2-Pyrimidinamine, 5-[7-methyl-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-;5-[7-Methyl-4-(morpholin-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine GNE 477
- 中文名:
- GNE 477
- 中文别名:
- 化合物GNE 477;双重PI3K/MTOR抑制剂(GNE-477);5-(7-甲基-6-((4-(甲基磺酰基)哌嗪-1-基)甲基)-4-吗啉噻吩并[3,2-D]嘧啶-2-基)嘧啶-2-胺
- CBNumber:
- CB62621135
- 分子式:
- C21H28N8O3S2
- 分子量:
- 504.63
- MOL File:
- 1032754-81-6.mol
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GNE 477化学性质
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密度:
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1.51±0.1 g/cm3(Predicted)
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储存条件:
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Desiccate at -20°C
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溶解度:
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insoluble in H2O; insoluble in EtOH; ≥16.69 mg/mL in DMSO with gentle warming
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形态:
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Powder
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酸度系数(pKa):
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4.22±0.10(Predicted)
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颜色:
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Light yellow to yellow
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GNE 477性质、用途与生产工艺
GNE-477是有效的PI3K/mTOR抑制剂,对PI3Kα的IC50值为4 nM,对mTOR的Kiapp值为21 nM。
Target | Value |
PI3Kα
(Cell-free assay)
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4 nM
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mTOR
(Cell-free assay)
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21 nM(Ki app)
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mTOR
(Cell-free assay)
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21 nM(Ki app)
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GNE 477
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-11042 | GNE 477 GNE-477 | 1032754-81-6 | 1mg | 800元 |
2024/08/19 | HY-11042 | GNE 477 GNE-477 | 1032754-81-6 | 5mg | 1700元 |
1032754-81-6, GNE 477 相关搜索:
- 药靶配体
- 细胞生物学试剂
- C21H28N8O3S2
- 5-(7-甲基-6-((4-(甲基磺酰基)哌嗪-1-基)甲基)-4-吗啉噻吩并[3,2-D]嘧啶-2-基)嘧啶-2-胺
- 化合物GNE 477
- 双重PI3K/MTOR抑制剂(GNE-477)
- 1032754-81-6
- mTOR,Phosphoinositide 3-kinase,GNE-477,Inhibitor,Mammalian target of Rapamycin,GNE477,inhibit,PI3K
- 5-(7-Methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
- 2-Pyrimidinamine, 5-[7-methyl-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
- CS-1884
- 5-(7-Methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-
- 5-[7-Methyl-4-(morpholin-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine GNE 477
- 5-[7-Methyl-4-(Morpholin-4-yl)-6-[(4-Methylsulfonylpiperazin-1-yl)Methyl]thieno[3,2-d]pyriMidin-2-yl]pyriMidin-2-aMine
- GNE 477