N-乙酰-2-苄基色胺
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- CAS号:
- 117946-91-5
- 英文名:
- LUZINDOLE
- 英文别名:
- N-0774;LUZINDOLE;Luzindole N;Luzindole Solution, 100ppm;N-ACETYL-2-BENZYLTRYPTAMINE;2-Benzyl-N-acetyltryptaMine;LuzindoleN-Acetyl-2-benzyltryptamine;N-(2-(2-benzyl-1H-indol-3-yl)ethyl)acetamide;n-[2-[2-(phenylmethyl)-1h-indol-3-yl]ethyl]acetamide;AcetaMide, N-[2-[2-(phenylMethyl)-1H-indol-3-yl]ethyl]-
- 中文名:
- N-乙酰-2-苄基色胺
- 中文别名:
- 褪黑素受体拮抗剂;N-乙酰-2-苄基色胺;N-乙酰基-2-苄基色胺;N-乙酰-2-苄基色胺溶液,100PPM;LUZINDOLE N-乙酰基-2-苄基色胺;N-(2-(2-苄基-1H-吲哚-3-基)乙基)乙酰胺;N-[2-[2-(苯基甲基)-1H-吲哚-3-基]乙基]乙酰胺
- CBNumber:
- CB6268781
- 分子式:
- C19H20N2O
- 分子量:
- 292.37
- MOL File:
- 117946-91-5.mol
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N-乙酰-2-苄基色胺化学性质
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熔点:
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44-46°C
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沸点:
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434.31°C (rough estimate)
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密度:
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1.1045 (rough estimate)
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折射率:
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1.6140 (estimate)
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储存条件:
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-20°C
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溶解度:
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DMSO: 5 mg/mL
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形态:
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White to off-white crystalline solid.
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酸度系数(pKa):
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16.36±0.46(Predicted)
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颜色:
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Off-White to Yellow
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水溶解性:
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Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water.
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稳定性:
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Store at -20°C
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CAS 数据库:
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117946-91-5(CAS DataBase Reference)
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N-乙酰-2-苄基色胺性质、用途与生产工艺
Luzindole (N-0774) 是一种选择性褪黑素受体 (melatonin receptor) 拮抗剂。Luzindole 优先靶向 MT2 (Mel1b),对于人 MT2 和 MT1 的 Ki 值分别为 10.2 和 158 nM。Luzindole 抑制实验性自身免疫性脑脊髓炎,并发挥抗抑郁样活性。
Ki :10.2 nM (human MT2), 158 nM (human MT1)
Luzindole (N-0774) (5-10 μg/ml) inhibits antigen-specific proliferation of the MBP-reactive LV-4 T cell line.
Luzindole (N-0774) (30 mg/kg; i.p.; days 0-5) suppresses experimental autoimmune encephalomyelitis.
Luzindole (N-0774) (30 mg/kg i.p.) reduces the time of immobility in a dose-dependent manner, the effect being more pronounced at midnight (60% reduction) than at noon (39% reduction). The effect of luzindole is time-dependent, showing a maximal effect at 60 min. The anti-immobility effect of luzindole (10 mg/kg i.p.) is prevented by the administration of melatonin (30 mg/kg i.p.). Luzindole (30 mg/kg i.p.) did not modify the time of immobility either at noon or midnight in the albino ND/4 mouse, or in the C57BL/6J mouse, which does not produce melatonin.
Animal Model:
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Twenty-three- to 12-week-old(SJL X PL/J ) F1 mice
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Dosage:
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30 mg/kg
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Administration:
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i.p.; days 0-5 (between 23: 00 and 1: 00 under conditions of minimal lighting)
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Result:
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Effectively prevented experimental autoimmune encephalomyelitis.
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N-乙酰-2-苄基色胺
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-101254 | N-乙酰-2-苄基色胺 Luzindole | 117946-91-5 | 1mg | 760元 |
2024/01/25 | HY-101254 | N-乙酰-2-苄基色胺 Luzindole | 117946-91-5 | 5mg | 1900元 |
N-乙酰-2-苄基色胺
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117946-91-5, N-乙酰-2-苄基色胺 相关搜索:
- Aromatics
- Aromatics Compounds
- Melatonin receptor
- 配体家族
- 合成有机化合物配体
- 合成
- LUZINDOLE N-乙酰基-2-苄基色胺
- N-乙酰基-2-苄基色胺
- N-乙酰-2-苄基色胺溶液,100PPM
- 褪黑素受体拮抗剂
- N-乙酰-2-苄基色胺
- N-[2-[2-(苯基甲基)-1H-吲哚-3-基]乙基]乙酰胺
- N-(2-(2-苄基-1H-吲哚-3-基)乙基)乙酰胺
- 117946-91-5
- Luzindole N
- Luzindole Solution, 100ppm
- AcetaMide, N-[2-[2-(phenylMethyl)-1H-indol-3-yl]ethyl]-
- 2-Benzyl-N-acetyltryptaMine
- N-(2-(2-benzyl-1H-indol-3-yl)ethyl)acetamide
- LuzindoleN-Acetyl-2-benzyltryptamine
- N-0774
- N-ACETYL-2-BENZYLTRYPTAMINE
- N-[2-[2-(Phenylmethyl)-1H-indol-3-yl]ethyl]acetamide, N-Acetyl-2-benzyltryptamine
- n-[2-[2-(phenylmethyl)-1h-indol-3-yl]ethyl]acetamide
- LUZINDOLE