HKI 357
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- CAS号:
- 848133-17-5
- 英文名:
- HKI 357
- 英文别名:
- HKI 357;Inhibitor,HKI-357,ErbB-1,HER1,inhibit,NSCLCs,Epidermal growth factor receptor,HKI 357,EGFR,ERBB2,HKI357;(2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;2-Butenamide, N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
- 中文名:
- HKI 357
- 中文别名:
- 化合物HKI-357;化合物 T11569;HKI 357,ERBB2和EGFR的双重不可逆抑制剂;(E)-N-(4-((3-氯-4-((3-氟苄基)氧基)苯基)氨基)-3-氰基-7-乙氧基喹啉-6-基)-4-(二甲基氨基)丁-2-烯酰胺
- CBNumber:
- CB63037308
- 分子式:
- C31H29ClFN5O3
- 分子量:
- 574.05
- MOL File:
- 848133-17-5.mol
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HKI 357化学性质
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沸点:
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747.6±60.0 °C(Predicted)
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密度:
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1.34±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble to 100 mM in DMSO and to 25 mM in ethanol
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形态:
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Powder
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酸度系数(pKa):
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12.37±0.43(Predicted)
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HKI 357性质、用途与生产工艺
HKI-357 是 EGFR 和 ERBB2 的不可逆双重抑制剂，IC50 分别为 34 nM 和 33 nM。HKI-357 抑制 EGFR 自磷酸化 (检测位点为 Y1068)，及 AKT 和 MAPK 磷酸化。
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EGFR
34 nM (IC
50
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ErbB2
33 nM (IC
50
)
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HKI-357 (0.01-10 μM) is effective in suppressing ligand-induced EGFR autophosphorylation and its downstream signaling, as determined by AKT and MAPK phosphorylation in NCI-H1975 cells.
HKI-357 also is effective in suppressing EGFR autophosphorylation (measured at residue Y1068), and AKT and MAPK phosphorylation in parental NCI-H1650 cells harboring the delE746-A750 EGFR mutation.
Western Blot Analysis
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Cell Line:
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NCI-H1975 bronchoalveolar cell line
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Concentration:
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0.01, 0.01, 0.1, 1 and 10 μM
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Incubation Time:
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Result:
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Suppressed ligand-induced EGFR autophosphorylation and its downstream signaling AKT and MAPK phosphorylation.
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HKI 357
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-103443 | HKI 357
HKI-357 | 848133-17-5 | 10mg | 2900元 |
| 2024/04/30 | HY-103443 | HKI 357
HKI-357 | 848133-17-5 | 50 mg | 9400元 |
848133-17-5, HKI 357 相关搜索:
- 酶
- C31H29ClFN5O3
- HKI 357,ERBB2和EGFR的双重不可逆抑制剂
- (E)-N-(4-((3-氯-4-((3-氟苄基)氧基)苯基)氨基)-3-氰基-7-乙氧基喹啉-6-基)-4-(二甲基氨基)丁-2-烯酰胺
- 化合物HKI-357
- 化合物 T11569
- 848133-17-5
- Inhibitor,HKI-357,ErbB-1,HER1,inhibit,NSCLCs,Epidermal growth factor receptor,HKI 357,EGFR,ERBB2,HKI357
- (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
- 2-Butenamide, N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
- HKI 357