213546-53-3
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- CAS号:
- 213546-53-3
- 英文名:
- NFκB Inhibitor
- 英文别名:
- SN50;NFkB Inhibitor;NF-KAPPA-B SN50;NF-κB Inhibitor, SN50;NF-KAPPAB INHIBITOR SN50;NFκB Inhibitor inhibitor;AAVALLPAVLLALLAPVQRKRQKLMP;NF-κB Inhibitor, SN50, >=97%;NUCLEAR FACTOR NF-B INHIBITOR SN50;NUCLEAR FACTOR NF-KAPPA-B INHIBITOR SN50
- 中文名:
- 213546-53-3
- 中文别名:
- 化合物 T12942;易位抑制剂多肽SN50;H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-LYS-LEU-MET-PRO-OH
- CBNumber:
- CB6315148
- 分子式:
- C129H230N36O29S
- 分子量:
- 2781.5
- MOL File:
- 213546-53-3.mol
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213546-53-3化学性质
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密度:
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1.36±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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形态:
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film
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颜色:
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colorless
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水溶解性:
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Water : ≥ 50 mg/mL (17.98 mM)
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213546-53-3性质、用途与生产工艺
SN50 (NF-κB SN50)是一种可渗透细胞的NF-κB抑制肽，由Kaposi成纤维细胞生长因子信号肽组成。SN50抑制NF-κB的活化并减轻呼吸机诱发的肺损伤。
Pretreatment with SN50 results in a significant reduction in amount of PI-positive cells at 12, 24, and 48 h time-point post TBI compared with vehicle-treated groups. Topical SN50 suppresses nuclear factor-κB activation in local cells and reduces the incidence of epithelial defects/ulceration in healing corneas. Myofibroblast generation, macrophage invasion, activity of matrix metalloproteinases, basement membrane destruction, and expression of cytokines are all decreased in treated corneas compared with controls. Treating the human gastric cancer cells SGC7901 with SN50 could significantly enhance the effects of LY294002 on inducing cell death after 24 h. SN50 can inhibit translocation of NF-kB and production of inflammatory cytokines that are implicated in lipopolysaccharide (LPS)-induced lung injury.
Treatment with SN50 accelerates the recovery of motor functional outcome from 1st to 4th day. Animals subjected to SN50 pretreatment demonstrate a significant decrease in the visuospatial learning latencies relative to the control group at 7 and 8 days post-TBI. Pretreatment with SN50 results in a significant reduction of NF-κB p65 protein levels from 6 to 48 h post-TBI and TNF-a protein levels from 12 to 48 h post-TBI.
213546-53-3
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-P0151 | 213546-53-3
SN50 | 213546-53-3 | 1mg | 900元 |
| 2024/01/25 | HY-P0151 | 213546-53-3
SN50 | 213546-53-3 | 5mg | 3600元 |
213546-53-3, 213546-53-3 相关搜索:
- 多肽
- 目录肽
- 标准品
- C129H230N36O29S
- 易位抑制剂多肽SN50
- 化合物 T12942
- H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-LYS-LEU-MET-PRO-OH
- 213546-53-3
- NFκB Inhibitor inhibitor
- L-Proline, L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-L-lysyl-L-leucyl-L-methionyl-
- NF-κB Inhibitor, SN50
- NFkB Inhibitor
- NF-κB Inhibitor, SN50, >=97%
- FGF-4 Precursor (7-22) (huMan)-EBP-1 (359-368) (huMan), HST-1 Precursor (7-22) (huMan)-DNA-Binding Factor KBF1 (359-368) (huMan), Fibroblast Growth Factor-4 Precursor (7-22) (huMan)-Nuclear Factor NF-ΚB p105 Subunit (359-368) (huMan) TFA
- SN50
- NUCLEAR FACTOR NF-KAPPA-B INHIBITOR SN50
- NUCLEAR FACTOR NF-B INHIBITOR SN50
- NF-KAPPAB INHIBITOR SN50
- NF-KAPPAB SN50, CELL-PERMEABLE INHIBITORY PEPTIDE
- NF-KAPPA-B SN50, CELL-PERMEABLE INHIBITOR PEPTIDE
- NF-KAPPA-B SN50
- AAVALLPAVLLALLAPVQRKRQKLMP
- HST-1 PRECURSOR (7-22) (HUMAN)-DNA-BINDING FACTOR KBF1 (359-368) (HUMAN)
- H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-LYS-LEU-MET-PRO-OH
- FIBROBLAST GROWTH FACTOR-4 PRECURSOR (7-22) (HUMAN)-NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT (359-368) (HUMAN)
- FGF-4 PRECURSOR (7-22) (HUMAN)-EBP-1 (359-368) (HUMAN)