DEHYDROCORYDALINE (CHLORIDE)
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- CAS号:
- 10605-03-5
- 英文名:
- Dehydrocorydaline chloride
- 英文别名:
- Dehydrocorydaline chloride;13-Methylpalmatine chloride;Dehydrocorydaline chloride, 99.95%;inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
- 中文名:
- DEHYDROCORYDALINE (CHLORIDE)
- 中文别名:
- 盐酸脱氢紫堇碱;盐酸去氢紫堇碱;盐酸脱氢紫堇硷;盐酸脱氢延胡索碱;盐酸去氢延胡索碱;盐酸脱氢紫堇碱, 99.95%;化合物DEHYDROCORYDALINE CHLORIDE
- CBNumber:
- CB63152944
- 分子式:
- C22H24ClNO4
- 分子量:
- 401.88326
- MOL File:
- 10605-03-5.mol
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DEHYDROCORYDALINE (CHLORIDE)化学性质
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熔点:
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191-193 °C (decomp)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 20 mg/ml
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形态:
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A solid
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DEHYDROCORYDALINE (CHLORIDE)性质、用途与生产工艺
Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是从中药延胡索 Corydalis yanhusuo 中分离得到的一种生物碱。Dehydrocorydaline 调节 Bax,Bcl-2 蛋白表达;激活 caspase-7,caspase-8,并使 PARP 失活。Dehydrocorydaline chloride 能增强 p38 MAPK 活化,具有抗炎、抗癌等功效。。Dehydrocorydaline chloride 具有强大的抗疟疾作用,并具低细胞毒性 (细胞生存力> 90%), P. falciparum 3D7 strain (IC50=38 nM)。
Treatment of C2C12 myoblasts with 500 nM Dehydrocorydaline increases the expression levels of muscle-specific proteins, including MyoD, myogenin and myosin heavy chain. Treatment with Dehydrocorydaline elevates p38 MAPK activation and the interaction of MyoD with an E protein. Furthermore, defects in differentiation-induced p38 MAPK activation and myoblast differentiation induced by depletion of the promyogenic receptor protein Cdo in C2C12 myoblasts are restored by Dehydrocorydaline treatment. Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose- dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression. Furthermore, dehydrocorydaline induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9. These results show that dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.
Dehydrocorydaline (3.6, 6 or 10 mg/kg, i.p.) shows a dose-dependent antinociceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test, dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.
DEHYDROCORYDALINE (CHLORIDE)
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-N0674A | Dehydrocorydaline chloride | | 1 mg | 956元 |
2024/01/25 | HY-N0674A | DEHYDROCORYDALINE (CHLORIDE) Dehydrocorydaline chloride | 10605-03-5 | 5mg | 1900元 |
DEHYDROCORYDALINE (CHLORIDE)
生产厂家
10605-03-5, DEHYDROCORYDALINE (CHLORIDE) 相关搜索:
- 盐酸脱氢紫堇硷
- 盐酸脱氢延胡索碱
- 盐酸去氢紫堇碱
- 盐酸去氢延胡索碱
- 化合物DEHYDROCORYDALINE CHLORIDE
- 盐酸脱氢紫堇碱
- 盐酸脱氢紫堇碱, 99.95%
- 10605-03-5
- inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
- 13-Methylpalmatine chloride
- Dehydrocorydaline chloride, 99.95%
- Dehydrocorydaline chloride