432499-63-3
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- CAS号:
- 432499-63-3
- 英文名:
- 4E2RCat
- 英文别名:
- 4E2RCat;Eukaryotic Initiation Factor;5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid;4E-2RCat,Virus Protease,4E2RCat,Inhibitor,inhibit,Autophagy,Eukaryotic Initiation Factor (eIF);5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid[4E2RCat;Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
- 中文名:
- 432499-63-3
- 中文别名:
- 化合物4E2RCAT;化合物 T14044;5-(5-((3-苄基-4-氧代-2-硫噻唑烷-5-亚基)甲基)呋喃-2-基)-2-氯苯甲酸
- CBNumber:
- CB63167593
- 分子式:
- C22H14ClNO4S2
- 分子量:
- 455.93
- MOL File:
- 432499-63-3.mol
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432499-63-3化学性质
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沸点:
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659.0±65.0 °C(Predicted)
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密度:
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1.56±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 15.5 mg/mL (34.00 mM)
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酸度系数(pKa):
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2.72±0.25(Predicted)
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432499-63-3性质、用途与生产工艺
4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5 μM。
IC50: 13.5 μM (eIF4E-eIF4G)
4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner.
4E2RCat inhibits protein synthesis
in vivo
and it is not a consequence of increased cell death.
432499-63-3
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100733 | 432499-63-3
4E2RCat | 432499-63-3 | 1mg | 1100元 |
| 2024/01/25 | HY-100733 | 432499-63-3
4E2RCat | 432499-63-3 | 5mg | 2700元 |
432499-63-3, 432499-63-3 相关搜索:
- C22H14ClNO4S2
- 化合物4E2RCAT
- 化合物 T14044
- 5-(5-((3-苄基-4-氧代-2-硫噻唑烷-5-亚基)甲基)呋喃-2-基)-2-氯苯甲酸
- 432499-63-3
- 4E-2RCat,Virus Protease,4E2RCat,Inhibitor,inhibit,Autophagy,Eukaryotic Initiation Factor (eIF)
- 5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid[4E2RCat
- 5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid
- Eukaryotic Initiation Factor
- Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
- 4E2RCat