PIM1/2 KINASE INHIBITOR VI
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- CAS号:
- 587852-28-6
- 英文名:
- SMI-16a
- 英文别名:
- SMI-16a;SMI-16A;SMI 16A;SMI16A;PIM1/2 Kinase Inhibitor VI;SMI-16a(PIM1/2 Kinase Inhibitor VI);5-(4-propoxybenzylidene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]-;SMI-16a,SMI 16a,inhibit,SMI16a,Pim,Inhibitor,Pim kinases
- 中文名:
- PIM1/2 KINASE INHIBITOR VI
- 中文别名:
- 化合物SMI-16A;PIM激酶抑制剂(SMI-16A);5-(4-丙氧基亚苄基)噻唑烷-2,4-二酮
- CBNumber:
- CB63313558
- 分子式:
- C13H13NO3S
- 分子量:
- 263.31
- MOL File:
- 587852-28-6.mol
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PIM1/2 KINASE INHIBITOR VI化学性质
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熔点:
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186.3-188.4 °C
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密度:
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1.303±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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Ethanol:3.0(Max Conc. mg/mL);11.39(Max Conc. mM)
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形态:
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A solid
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酸度系数(pKa):
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7.27±0.20(Predicted)
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PIM1/2 KINASE INHIBITOR VI性质、用途与生产工艺
SMI-16a是选择性Pim激酶抑制剂，对Pim1和Pim2的IC50值分别为150 nM和20 nM。
| Target | Value |
Pim2
()
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20 nM
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Pim1
()
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150 nM
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SMI-16a has excellent potency for inhibition of both Pim-1 and Pim-2. Treatment with Pim-2 short-interference RNA as well as the Pim inhibitor SMI-16a successfully restores osteoblastogenesis suppressed by all the above inhibitory factors and MM cells. The SMI-16a treatment potentiates BMP-2-mediated anabolic signaling while suppressing TGF-β signaling.
Mice tolerate intraperitoneal dose of SMI-16a is 50 mg/kg daily for 5 days, while 100 mg/kg is overtly toxic. Treatment of the animals with SMI-16a for 5 days per week reduces the growth of tumors by approximately 50% and does not cause a loss of body weight. Subchronic dosing with SMI-16a does not affect the levels of red, white blood cells, including lymphocytes, monocytes, and granulocytes, indicating that the compound does not have myelosuppressive effects. SMI-16a does not have toxicity toward the liver as the albumin, alkaline phosphatase, and alanine aminotransferase levels are unchanged . SMI-16a effectively prevents bone destruction while suppressing MM tumor growth in MM animal models.
PIM1/2 KINASE INHIBITOR VI
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101947 | SMI-16a | | 1 mg | 304元 |
| 2024/01/25 | HY-101947 | PIM1/2 KINASE INHIBITOR VI
SMI-16a | 587852-28-6 | 5mg | 800元 |
PIM1/2 KINASE INHIBITOR VI
生产厂家
587852-28-6, PIM1/2 KINASE INHIBITOR VI 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 5-(4-丙氧基亚苄基)噻唑烷-2,4-二酮
- 化合物SMI-16A
- PIM激酶抑制剂(SMI-16A)
- 587852-28-6
- 5-(4-propoxybenzylidene)thiazolidine-2,4-dione
- SMI-16a,SMI 16a,inhibit,SMI16a,Pim,Inhibitor,Pim kinases
- 2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]-
- SMI-16A;SMI 16A;SMI16A
- SMI-16a(PIM1/2 Kinase Inhibitor VI)
- PIM1/2 Kinase Inhibitor VI
- SMI-16a