QL9
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- CAS号:
- 159646-83-0
- 英文名:
- QL9
- 英文别名:
- QL9;L-Leucine, L-glutaminyl-L-leucyl-L-seryl-L-prolyl-L-phenylalanyl-L-prolyl-L-phenylalanyl-L-α-aspartyl-
- 中文名:
- QL9
- 中文别名:
- TCR识别抗原多肽
- CBNumber:
- CB63334980
- 分子式:
- C52H74N10O14
- 分子量:
- 1063.22
- MOL File:
- 159646-83-0.mol
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QL9化学性质
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沸点:
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1463.5±65.0 °C(Predicted)
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密度:
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1.313±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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3.24±0.10(Predicted)
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QL9性质、用途与生产工艺
QL9 是针对2C T细胞受体 (TCR) 的高亲和力同种异体抗原。
Mouse T cell clone 2C recognizes two different major histocompatibility (MHC) ligands, the self MHC K
b
and the allogeneic MHC L
d
. Two distinct peptides, SIY (SIYRYYGL) and QL9 (QLSPFPFDL), act as strong and specific agonists when bind to K
b
and L
d
, respectively. QL9 binding to MHC L
d
is influenced by the majority of peptide side chains, distributed across the entire length of the peptide. Findings with both systems, but QL9-L
d
in particular, suggest that many single-residue substitutions, introduced into peptides to improve their binding to MHC and thus their vaccine potential, could impair T cell reactivity due to their dual impact on TCR binding. T cell activation assays are performed to measure effects of peptide SIY and QL9 residues on T cell function.
QL9
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上游原料
下游产品
159646-83-0, QL9 相关搜索:
- 目录肽
- C52H74N10O14
- TCR识别抗原多肽
- 159646-83-0
- L-Leucine, L-glutaminyl-L-leucyl-L-seryl-L-prolyl-L-phenylalanyl-L-prolyl-L-phenylalanyl-L-α-aspartyl-
- QL9