BTM-1086
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- CAS号:
- 72293-17-5
- 英文名:
- 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-[(4-methyl-1-piperazinyl)methyl]-2-phenyl-, (2R,3S)-rel-
- 英文别名:
- BTM1086,BTM 1086;1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-[(4-methyl-1-piperazinyl)methyl]-2-phenyl-, (2R,3S)-rel-
- 中文名:
- BTM-1086
- 中文别名:
- 化合物 T10008
- CBNumber:
- CB63339541
- 分子式:
- C21H25N3OS
- 分子量:
- 367.51
- MOL File:
- 72293-17-5.mol
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BTM-1086化学性质
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熔点:
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257-260 °C
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沸点:
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558.2±50.0 °C(Predicted)
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密度:
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1.176±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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14.11±0.60(Predicted)
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BTM-1086性质、用途与生产工艺
BTM-1086是一种有效的抗溃疡和胃分泌抑制剂。
Functional and binding experiments shows that the (-) enantiomer (BTM-1086) has a high affinity (pK
i
=8.31-9.15) for the three muscarinic receptor subtypes in guinea-pig cortex (M1), heart (M2) and salivary glands (M3).
BTM-1086 prevents the development of ulcer at a dose of 0.1 to 1 mg/kg, p.o., but only weakly inhibits the histamine induced gastric ulcer. The inhibitory activities of BTM-1086 are significantly higher than those of atropine sulfate. In the healing experiment with the acetic acid-induced stomach ulcer, BTM-1086 (1 mg/kg/day , p.o., x14) shows a significant healing effect, which is higher than that of propantheline bromide . BTM-1086 at a dose of 0.2 mg/kg , i.d., remarkably inhibits the gastric secretion 6 hr after pylorus ligation. The aspirin-induced reductions of the total acid and K
+
as well as the increments of the volume and Na
+
in the gastric secretion are prevented dose-dependently by pretreatment with BTM-1086. The LD
50
value by oral, s.c., and i.v. administration with this compound is 880, 630 and 113 mg/kg, respectively, for male rats and 830, 650 and 119 mg/kg, respectively, for female rats.
BTM-1086
上下游产品信息
上游原料
下游产品
72293-17-5, BTM-1086 相关搜索:
- 化合物 T10008
- 72293-17-5
- BTM1086,BTM 1086
- 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-[(4-methyl-1-piperazinyl)methyl]-2-phenyl-, (2R,3S)-rel-