NEUROPEPTIDE VF (124-131) (HUMAN)
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- CAS号:
- 311309-27-0
- 英文名:
- H-VAL-PRO-ASN-LEU-PRO-GLN-ARG-PHE-NH2
- 英文别名:
- NPVF;V-8-F-NH2;Rat RFRP-3;VPNLPQRF-NH2;V-8-F-NH2, NPVF;H2N-VPNLPQRF-AMIDE;RFamide-related peptide-3;Neuropeptide VF (124-131);NEUROPEPTIDE VF (124-131) (HUMAN);RFRP-3 human trifluoroacetate salt
- 中文名:
- NEUROPEPTIDE VF (124-131) (HUMAN)
- 中文别名:
- 人GNIH 肽同源物;RFRP 3(人类)三氟乙酸盐;受体激动剂多肽NEUROPEPTIDENPVF-AMIDE
- CBNumber:
- CB6345516
- 分子式:
- C45H72N14O10
- 分子量:
- 969.14
- MOL File:
- 311309-27-0.mol
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NEUROPEPTIDE VF (124-131) (HUMAN)化学性质
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密度:
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1.45±0.1 g/cm3(Predicted)
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储存条件:
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-15°C
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酸度系数(pKa):
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13.23±0.20(Predicted)
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形态:
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powder
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颜色:
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white to off-white
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水溶解性:
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Soluble to 2 mg/ml in 20% acetonitrile / Water
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NEUROPEPTIDE VF (124-131) (HUMAN)性质、用途与生产工艺
RFRP-3 (Neuropeptide VF(124-131))(human)，一种人GnIH 肽同源物，是一种促性腺激素分泌抑制 Ca2+ 动员的有效抑制剂。RFRP-3(human) 是一种NPFF1 受体激动剂，它抑制 forskolin (HY-15371) 诱导的 cAMP 生成的 IC50 值为 0.7 nM。
RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC
50
of 0.7 nM.
Scatchard-plot analysis shows that
125
I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K
d
value and the B
max
values are 0.19 nM and 1.3 pM, respectively.RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K
d
= 0.19 nM).RFRP-3 (10
-8
to 10
-14
M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination.
NEUROPEPTIDE VF (124-131) (HUMAN)
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NEUROPEPTIDE VF (124-131) (HUMAN)
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311309-27-0, NEUROPEPTIDE VF (124-131) (HUMAN) 相关搜索:
- 药靶配体
- 目录肽
- 目录多肽
- C45H72N14O10
- RFRP 3(人类)三氟乙酸盐
- 受体激动剂多肽NEUROPEPTIDENPVF-AMIDE
- 人GNIH 肽同源物
- 311309-27-0
- VPNLPQRF-NH2
- Rat RFRP-3
- L-Phenylalaninamide, L-valyl-L-prolyl-L-asparaginyl-L-leucyl-L-prolyl-L-glutaminyl-L-arginyl-
- (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
- RFRP-3 human trifluoroacetate salt
- RFamide-related peptide-3
- Neuropeptide VF (124-131)
- V-8-F-NH2, NPVF
- Neuropeptide VF (124-131) (huMan)
V-8-F-NH2, NPVF
- H2N-VPNLPQRF-AMIDE
- H-VAL-PRO-ASN-LEU-PRO-GLN-ARG-PHE-NH2
- V-8-F-NH2
- NPVF
- NEUROPEPTIDE VF (124-131) (HUMAN)
- NEUROPEPTIDE NPVF FRAGMENT AMIDE [HOMO SAPIENS]