2137030-98-7
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- CAS号:
- 2137030-98-7
- 英文名:
- Ensartinib dihydrochloride
- 英文别名:
- Ensartinib 2HCl;X-396 hydrochloride;X-396 dihydrochloride;Ensartinib hydrochloride;Ensartinib dihydrochloride;Ensartinib hydrochloride ( X396);Ensartinib (X-396) dihydrochloride;Ensartinib,X396,Cluster of differentiation 246,X 396,Inhibitor,CD246,Anaplastic lymphoma kinase (ALK),Anaplastic lymphoma kinase,c-Met/HGFR,ALK tyrosine kinase receptor,Ensartinib hydrochloride,inhibit,X-396
- 中文名:
- 2137030-98-7
- 中文别名:
- 恩沙替尼盐酸盐;恩沙替尼二盐酸盐;化合物ENSARTINIB (X-396) DIHYDROCHLORIDE;6-氨基-5-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-N-[4-[[((3R,5S)-3,5-二甲基-1-哌嗪基]羰基]苯基]-3-哒嗪甲酰胺二盐酸盐
- CBNumber:
- CB64189028
- 分子式:
- C26H28Cl3FN6O3
- 分子量:
- 597.9
- MOL File:
- 2137030-98-7.mol
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2137030-98-7化学性质
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储存条件:
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0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
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形态:
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solid
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颜色:
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white
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水溶解性:
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Water : 5 mg/mL (7.88 mM)
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2137030-98-7性质、用途与生产工艺
Ensartinib (X-396)是一种有效的ALK抑制剂，对许多具有crizotinib抗性的ALK突变型和中枢神经系统转移具有高活性。它能有效地抑制野生型ALK和ALK变体（F1174, C1156Y, L1196M, S1206R, T1151和G1202R突变型），IC50小于4 nM。
| Target | Value |
TPM3-TRKA
(Cell-free assay)
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<1 nM
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TRKC
(Cell-free assay)
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<1 nM
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GOPC-ROS1
(Cell-free assay)
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<1 nM
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ALK
(Cell-free assay)
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<4 nM
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ALK variants
(Cell-free assay)
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<4 nM
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2137030-98-7
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-103714A | Ensartinib dihydrochloride | | 1 mg | 600元 |
| 2024/04/30 | HY-103714A | 2137030-98-7
Ensartinib hydrochloride | 2137030-98-7 | 5mg | 1500元 |
2137030-98-7, 2137030-98-7 相关搜索:
- APIS
- 药靶配体
- 对照品
- 恩沙替尼二盐酸盐
- 恩沙替尼盐酸盐
- 化合物ENSARTINIB (X-396) DIHYDROCHLORIDE
- 6-氨基-5-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-N-[4-[[((3R,5S)-3,5-二甲基-1-哌嗪基]羰基]苯基]-3-哒嗪甲酰胺二盐酸盐
- 2137030-98-7
- Ensartinib (X-396) dihydrochloride
- Ensartinib 2HCl
- Ensartinib,X396,Cluster of differentiation 246,X 396,Inhibitor,CD246,Anaplastic lymphoma kinase (ALK),Anaplastic lymphoma kinase,c-Met/HGFR,ALK tyrosine kinase receptor,Ensartinib hydrochloride,inhibit,X-396
- X-396 dihydrochloride
- Ensartinib hydrochloride ( X396)
- X-396 hydrochloride
- Ensartinib hydrochloride
- Ensartinib dihydrochloride