1370046-40-4
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- CAS号:
- 1370046-40-4
- 英文名:
- SSE15206
- 英文别名:
- SSE15206;SSE-15206;SSE 15206;SSE15206; SSE-15206; SSE 15206;1370046-40-4;5-phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide;Inhibitor,Apoptosis,Microtubule/Tubulin,inhibit,SSE 15206,SSE-15206,SSE15206;3-Phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide;4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide;1H-Pyrazole-1-carbothioamide, 4,5-dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-
- 中文名:
- 1370046-40-4
- 中文别名:
- SSE15206游离;化合物SSE15206;3-苯基-5-(3,4,5-三甲氧基苯基)-4,5-二氢-1H-吡唑-1-硫代酰胺
- CBNumber:
- CB64676751
- 分子式:
- C19H21N3O3S
- 分子量:
- 371.45
- MOL File:
- 1370046-40-4.mol
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1370046-40-4化学性质
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沸点:
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518.7±60.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO:112.0(Max Conc. mg/mL);301.52(Max Conc. mM)
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酸度系数(pKa):
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14.12±0.60(Predicted)
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1370046-40-4性质、用途与生产工艺
SSE15206 是一种微管 (microtubule) 聚合抑制剂，其在 HCT116 细胞中的 GI50 值为 197 nM，能克服多重耐药性。引起细胞中纺锤体形成不完全，从而导致 G2/M 阻滞，有丝分裂异常。
GI50: 197 nM (microtubule).
SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI
50
values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines.
Western Blot Analysis
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Cell Line:
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Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells.
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Concentration:
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5 × and 10 × GI
50
values (GI
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=197 nM in HCT-116 cells).
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Incubation Time:
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24 hours.
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Result:
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Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells.
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1370046-40-4
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-111425 | 1370046-40-4
SSE15206 | 1370046-40-4 | 5mg | 690元 |
| 2024/01/25 | HY-111425 | 1370046-40-4
SSE15206 | 1370046-40-4 | 10mM * 1mLin DMSO | 759元 |
1370046-40-4, 1370046-40-4 相关搜索:
- API
- 化合物SSE15206
- SSE15206游离
- 3-苯基-5-(3,4,5-三甲氧基苯基)-4,5-二氢-1H-吡唑-1-硫代酰胺
- 1370046-40-4
- 5-phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide
- Inhibitor,Apoptosis,Microtubule/Tubulin,inhibit,SSE 15206,SSE-15206,SSE15206
- 3-Phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
- 4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide
- 1H-Pyrazole-1-carbothioamide, 4,5-dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-
- SSE15206; SSE-15206; SSE 15206;1370046-40-4
- SSE-15206;SSE 15206
- SSE15206