5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile

生物活性靶点体外研究体内研究

CAS号:: 2120398-39-0

英文名:: 5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile

英文别名:: Chk1-IN-5;Chk-1-IN-5,Chk1IN5,Chk1 IN 5;5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile;2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-

中文名:: 5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile

中文别名:: 5-((5-(2-(3-氨基丙氧基)-4-氟-6-甲氧基苯基)-1H-吡唑-3-基)氨基)吡嗪-2-甲腈

CBNumber:: CB64841609

分子式:: C18H18FN7O2

分子量:: 383.38

MOL File:: 2120398-39-0.mol

化学性质安全信息用途供应商 7

5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile化学性质

储存条件:: Store at -20°C

安全信息

5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile性质、用途与生产工艺

生物活性

Chk1-IN-5 是有效的检查点激酶 1 (Chk1) 抑制剂。Chk1-IN-5 抑制 Chk1 磷酸化，并在结肠癌异种移植模型中抑制肿瘤生长。

体外研究

Chk1-IN-5 (compound 3; 0.4, 1.2, 3.7, 11.1, 33.3, 100 nM) inhibits Chk1 phosphorylation in the HT-29 colon cells.

Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells.
Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T _1/2 =3.8 hours) and higher exposure (CL=2.3 L/hr•kg; V _ss =6.4 L/kg; AUC=4531 ng/ml•h).

Animal Model:	Baib/c nude mice with HT-29 colon cancer cells
Dosage:	40 mg/kg
Administration:	IV; twice a week for 21 days
Result:	Inhibited tumor growth.

Animal Model:	Male SD rats (280-350 g)
Dosage:	10 mg/kg
Administration:	Via tail vein intravenous injection
Result:	Displayed a longer half-life (T _1/2 =3.8 hours) and higher exposure (CL=2.3 L/hr•kg; V _ss =6.4 L/kg; AUC=4531 ng/ml•h).

5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile 上下游产品信息

上游原料

下游产品

5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile 生产厂家

全球有 7家供应商 5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
苏州美诺医药科技有限公司	0512-0512-69561983 13914027025	he_qf@medinoah.com	中国	3380	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	中国	4022	58
TargetMol中国（陶术生物）	4008200310	marketing@tsbiochem.com	中国	24131	58
苏州键合化学试剂有限公司	0512-69561983 13914027025	he_qf@medinoah.com	中国	3001	58
江苏艾康生物医药研发有限公司	025-66113011 18112977050	cb5@aikonchem.com	中国	10529	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	中国	3719	58

2120398-39-0, 5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile 相关搜索:

C18H18FN7O2
5-((5-(2-(3-氨基丙氧基)-4-氟-6-甲氧基苯基)-1H-吡唑-3-基)氨基)吡嗪-2-甲腈
2120398-39-0
Chk-1-IN-5,Chk1IN5,Chk1 IN 5
Chk1-IN-5
2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-
5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile