MLN-4760
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- CAS号:
- 305335-31-3
- 英文名:
- MLN-4760
- 英文别名:
- MLN-4760;((S)-1-carboxy-2-(1-(3,5-dichlorobenzyl)-1H-imidazol-5-yl)ethyl)-L-leucine;L-Histidine, N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-;inhibit,Angiotensin-converting Enzyme (ACE),MLN 4760,Inhibitor,MLN-4760,MLN4760
- 中文名:
- MLN-4760
- 中文别名:
- 化合物MLN-4760;((S)-1-羧基-2-(1-(3,5-二氯苄基)-1H-咪唑-5-基)乙基)-L-亮氨酸
- CBNumber:
- CB64845021
- 分子式:
- C19H23Cl2N3O4
- 分子量:
- 428.31
- MOL File:
- 305335-31-3.mol
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MLN-4760化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: soluble
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形态:
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A solid
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MLN-4760性质、用途与生产工艺
MLN-4760 (compound 16) 是一种有效的、选择性的人 angiotensin-converting enzyme 2 (ACE2) 的抑制剂，IC50值为0.44 nM。MLN-4760 还抑制 bovine carboxypeptidase A (CPDA)，其IC50值为27 μM。
| Target | Value |
ACE2
(Cell-free assay)
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0.44 nM
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CPDA
(Cell-free assay)
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27 μM
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MLN-4760 is a potent and selective human ACE2 inhibitor (IC
50
, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes human testicular ACE (IC
50
, >100 μM) and bovine carboxypeptidase A (CPDA; IC
50
, 27 μM). MLN-4760 effectively quenches cleavage of the 7-Mca-YVADAPK(Dnp) in rhACE2. MLN-4760 shows pIC
50
at rhACE2 of 8.5±0.1 and at rhACE of 4.4±0.2. MLN-4760 also shows pIC
50
at rhACE2 of 4.7±0.1, 6.9±0.1 and at ACE of 4.4±0.1, 6.2±0.1 in murine heart and mononuclear cells (MNCs), resepctively.
MLN-4760 (100 μM, intracerebroventricular infusion for five days) significantly worsens neurological function at 4 h and 3 d post-stroke without significantly increasing infarct volume.
MLN-4760
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19414 | MLN-4760
MLN-4760 | 305335-31-3 | 1mg | 1550元 |
| 2024/04/30 | HY-19414 | MLN-4760
MLN-4760 | 305335-31-3 | 5mg | 3150元 |
305335-31-3, MLN-4760 相关搜索:
- 氨基酸
- ((S)-1-羧基-2-(1-(3,5-二氯苄基)-1H-咪唑-5-基)乙基)-L-亮氨酸
- 化合物MLN-4760
- 305335-31-3
- inhibit,Angiotensin-converting Enzyme (ACE),MLN 4760,Inhibitor,MLN-4760,MLN4760
- ((S)-1-carboxy-2-(1-(3,5-dichlorobenzyl)-1H-imidazol-5-yl)ethyl)-L-leucine
- L-Histidine, N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-
- MLN-4760