NL-1
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- CAS号:
- 188532-26-5
- 英文名:
- NL 1
- 英文别名:
- NL 1;5-(3,5-Di-tert-butyl-4-hydroxybenzyl)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-;Inhibitor,viability,Mitochondrial Metabolism,leukemia,NL-1,CISD1,NL1,antileukemic,MitoNEET,lymphoblastic,inhibit,B-Cell,Autophagy,acute,anti-cancer,NL 1
- 中文名:
- NL-1
- 中文别名:
- 化合物NL-1;5-(3,5-二叔丁基-4-羟基苄基)噻唑烷-2,4-二酮
- CBNumber:
- CB65417106
- 分子式:
- C18H25NO3S
- 分子量:
- 335.46
- MOL File:
- 188532-26-5.mol
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NL-1化学性质
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沸点:
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446.5±40.0 °C(Predicted)
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密度:
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1.167±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO: 250 mg/mL (745.25 mM)
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酸度系数(pKa):
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6.34±0.50(Predicted)
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NL-1性质、用途与生产工艺
NL-1 是一种具有抗白血病作用的 mitoNEET 抑制剂。NL-1 抑制 REH 和 REH/Ara-C 细胞生长，IC50 分别为 47.35 µM 和 56.26 µM。NL-1 介导的白血病细胞死亡需要激活自噬途径。
NL-1 (10-100 μM; 72 hours; REH, REH/Ara-C and ALL cell lines) treatment reduces the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner. NL-1 inhibits SUPB15, NALM6 with
IC
50
s of 29.48 µM, 94.26 µM, respectively. TOM1, BV173, NALM1 and JM1 all have similar
IC
50
values of around 60 µM for NL-1.
NL-1 (60 μM; 6 hours; REH, REH/Ara-C cell lines) treatment mediates autophagy, and inhibition of autophagy partially decreased NL-1-induced tumor cell death.
NL-1 pretreatment inhibits the chemotactic ability of both REH and REH/Ara-C cells to migrate towards multiple chemoattractants. The cells treated with NL1 shows a dose-dependent decrease in chemotaxis both in the REH and the REH/AraC cells.
Cell Proliferation Assay
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Cell Line:
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REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines
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Concentration:
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10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 100 μM
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Incubation Time:
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72 hours
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Result:
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Reduced the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner.
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Cell Autophagy Assay
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Cell Line:
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REH, REH/Ara-C cell lines
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Concentration:
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60 μM
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Incubation Time:
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6 hours
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Result:
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Induced cell autophagy.
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NL-1 (10 mg/kg; intraperitoneal injection; daily; for 5 days; female NSG mice) treatment shows antileukemic activity in an in vivo mouse ALL model.
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Animal Model:
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10 female NOD.Cg-
Prkdc
scid
Il2rg
tm1Wjl
/SzJ (NSG) mice (6-8 month old) injected with TOM-1 ALL cells
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Dosage:
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10 mg/kg
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Administration:
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Intraperitoneal injection; daily; for 5 days
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Result:
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Showed antileukemic activity in an in vivo mouse ALL model.
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NL-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-135231 | NL-1 | | 5 mg | 435元 |
| 2024/04/30 | HY-135231 | NL-1
NL-1 | 188532-26-5 | 10mM * 1mLin DMSO | 506元 |
188532-26-5, NL-1 相关搜索:
- 药靶配体
- 对照品
- 化合物NL-1
- 5-(3,5-二叔丁基-4-羟基苄基)噻唑烷-2,4-二酮
- 188532-26-5
- Inhibitor,viability,Mitochondrial Metabolism,leukemia,NL-1,CISD1,NL1,antileukemic,MitoNEET,lymphoblastic,inhibit,B-Cell,Autophagy,acute,anti-cancer,NL 1
- 5-(3,5-Di-tert-butyl-4-hydroxybenzyl)thiazolidine-2,4-dione
- 2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-
- NL 1