RADIOPROTECTIN-1
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- CAS号:
- 1622006-09-0
- 英文名:
- Radioprotectin-1
- 英文别名:
- Radioprotectin-1;Radioprotectin-1, 10 mM in DMSO;Benzoic acid, 5-chloro-2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-
- 中文名:
- RADIOPROTECTIN-1
- 中文别名:
- 化合物 T12684;化合物RADIOPROTECTIN-1;化合物RADIOPROTECTIN-1,10 MM DMSO 溶液
- CBNumber:
- CB65419827
- 分子式:
- C23H19ClN2O6S
- 分子量:
- 486.92
- MOL File:
- 1622006-09-0.mol
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RADIOPROTECTIN-1化学性质
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沸点:
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720.6±70.0 °C(Predicted)
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密度:
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1.490±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 125 mg/mL (256.72 mM);Water : < 0.1 mg/mL (insoluble)
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酸度系数(pKa):
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2.69±0.36(Predicted)
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形态:
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Solid
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颜色:
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White to light yellow
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RADIOPROTECTIN-1性质、用途与生产工艺
Radioprotectin-1 是一种高效特异性的溶血磷脂酸受体 2 (LPA2) 激动剂，EC50 值为 25 nM (鼠源 LPA2 亚型) 。
EC50: 25 nM (murine LPA
2
subtype)
Radioprotectin-1 is a potent agonist of LPA
2
with an EC
50
of 5 pM and functions as a full agonist at the human ortholog of LPA
2
.
Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA
2
either endogenously or after transfection.
Cell Viability Assay
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Cell Line:
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MEF cells , IEC-6 cells
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Concentration:
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0 μM, 0.1 μM, 0.3 μM, 1.0 μM,3 μM
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Incubation Time:
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15 minutes
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Result:
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Protected cells from apoptosis by γ-irradiation- and the radiomimetic chemotherapeutic
Adiamycin.
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Radioprotectin-1 is a high-potency specific agonist of the murine LPA
2
GPCR .
Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) .
Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA
2
GPCR in Lgr5
+
stem cells.
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Animal Model:
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8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI)
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Dosage:
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0.1 mg/kg, 0.3 mg/kg
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Administration:
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Subcutaneous injection; every 12 hours; for 3 days
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Result:
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Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS.
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RADIOPROTECTIN-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-114380 | Radioprotectin-1 | 1622006-09-0 | 1 mg | 915元 |
| 2025/05/22 | HY-114380 | RADIOPROTECTIN-1
Radioprotectin-1 | 1622006-09-0 | 5mg | 2225元 |
1622006-09-0, RADIOPROTECTIN-1 相关搜索:
- 抑制剂
- 化合物RADIOPROTECTIN-1,10 MM DMSO 溶液
- 化合物RADIOPROTECTIN-1
- 化合物 T12684
- 1622006-09-0
- Radioprotectin-1, 10 mM in DMSO
- Benzoic acid, 5-chloro-2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-
- Radioprotectin-1