SB 4
|
|
|
- CAS号:
- 100874-08-6
- 英文名:
- SB 4
- 英文别名:
- SB 4;SB 4 (Eticovo);BMP signaling agonist sb4;2-((4-Bromobenzyl)thio)benzo[d]oxazole;Benzoxazole, 2-[[(4-bromophenyl)methyl]thio]-;Inhibitor,SMAD,bmp,cell,inhibit,BMP signaling agonist sb4,BRE-luc,BMP signaling agonist sb 4,Transforming growth factor beta receptors,PREC,BMP signaling agonist sb-4,agonist,TGF-β Receptor
- 中文名:
- SB 4
- 中文别名:
- 化合物SB 4;SB 4,BMP4激动剂;2-((4-溴苄基)硫代)苯并[D]恶唑
- CBNumber:
- CB65830972
- 分子式:
- C14H10BrNOS
- 分子量:
- 320.2
- MOL File:
- 100874-08-6.mol
|
|
|
SB 4化学性质
-
熔点:
-
70-72 °C
-
|
-
沸点:
-
444.2±47.0 °C(Predicted)
-
|
-
密度:
-
1.57±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
0.92±0.10(Predicted)
-
|
SB 4性质、用途与生产工艺
SB 4 (Eticovo) 是一种 bone morphogenetic protein 4 (BMP4) signaling 的有效的选择性激动剂，其EC50值为74 nM。SB 4 (Eticovo) 可增强经典的BMP信号传导并激活 SMAD-1/5/9 磷酸化。
| Target | Value |
BMP4
(Cell-free assay)
|
74 nM(EC50)
|
BMP signaling agonist sb4 (0.05 μM-1 μM; 24 hours) induces phosphorylated SMAD-1/5/9 in a dose-dependent manner in PRECs cells under serum-starved conitions.
BMP signaling agonist sb4 (1 μM; 0-60 mins) enhances the efficacy of signaling at each concentration of rhBMP4 tested. This effect is most pronounced at low concentrations of rhBMP4, whereby sb4 increases BRE-luc expression 2-fold at 0.4 ng/ml of rhBMP4.
Western Blot Analysis
|
Cell Line:
|
Primary mouse kidney epithelial cells (PRECs)
|
|
Concentration:
|
0.05 μM-1 μM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Incresed p-SMAD-1/5/9 abundance in PRECs.
|
Western Blot Analysis
|
Cell Line:
|
BRE-Luc cells
|
|
Concentration:
|
1 μM
|
|
Incubation Time:
|
0min, 5 mins, 15 mins, 30 mins, 45 mins, 60 mins
|
|
Result:
|
Acted to stabilize p-SMAD-1/5/9 to enhance the transcriptional response.
|
SB 4
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-124697 | BMP signaling agonist sb4 | | 5 mg | 500元 |
| 2024/01/25 | HY-124697 | SB 4
BMP signaling agonist sb4 | 100874-08-6 | 10mM * 1mLin DMSO | 550元 |
100874-08-6, SB 4 相关搜索:
- SB 4,BMP4激动剂
- 化合物SB 4
- 2-((4-溴苄基)硫代)苯并[D]恶唑
- 100874-08-6
- Inhibitor,SMAD,bmp,cell,inhibit,BMP signaling agonist sb4,BRE-luc,BMP signaling agonist sb 4,Transforming growth factor beta receptors,PREC,BMP signaling agonist sb-4,agonist,TGF-β Receptor
- 2-((4-Bromobenzyl)thio)benzo[d]oxazole
- SB 4 (Eticovo)
- Benzoxazole, 2-[[(4-bromophenyl)methyl]thio]-
- SB 4
- BMP signaling agonist sb4