软木肟酸
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- CAS号:
- 38937-66-5
- 英文名:
- Suberohydroxamic acid
- 英文别名:
- ODHA;SBHA;[PTYR705]-STAT3;STAT3 (PTYR705);SUBEROHYDROXAMIC ACID;SUBERIC BISHYDROXAMATE;SuberohydroxaMic acid 95%;SuberoylBis-hydroxamicAci;suberic bishydroxamic acid;SUBEROYL BISHYDROXAMIC ACID
- 中文名:
- 软木肟酸
- 中文别名:
- 软木肟酸;次异羟肟酸;辛烷-1,8-二氧肟酸;N1,N8-二羟基辛烷二酰胺
- CBNumber:
- CB6673028
- 分子式:
- C8H16N2O4
- 分子量:
- 204.22
- MOL File:
- 38937-66-5.mol
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软木肟酸化学性质
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熔点:
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153-155 °C(lit.)
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密度:
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1.219±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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H2O: soluble
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酸度系数(pKa):
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9.18±0.20(Predicted)
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形态:
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lyophilized powder
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颜色:
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White to Light Beige
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稳定性:
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Hygroscopic
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软木肟酸性质、用途与生产工艺
Suberoylbis-hydroxamic酸(软木肟酸)作为第二代异羟肟酸类组蛋白去乙酰化酶抑制剂,能够抑制组蛋白去乙酰化酶中HDAC1和HDAC3的活性,小剂量、低浓度时可诱导肿瘤分化,并选择性地抑制肿瘤生长而对正常细胞无明显不良反应。通过对乳腺癌的研究发现软木肟酸呈时间、剂量依赖性抑制乳腺癌细胞增殖,使其停滞于G0~G1期。ChemicalBook
软木肟酸是一种组蛋白去乙酰化酶抑制剂,它可能具备激活Notch1信号通路的功能。应用Western实验检验Notch1信号通路被激活后所表达的活性蛋白NICD,来判断软木肟酸对Notch1信号通路的作用。
Suberohydroxamic acid (suberic bishydroxamic acid)是竞争性HDAC抑制剂,对HDAC1和HDAC3的IC50分别为0.25 μM和0.3 μM。
Target | Value |
HDAC1
(Cell-free assay)
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0.25 μM
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HDAC3
(Cell-free assay)
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0.3 μM
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Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10–15% apoptosis), resulting in 45–50% cell death.Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL,which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells.Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells.
Apoptosis Analysis
Cell Line:
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MM-BI and Ist-Mes2 cells
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Concentration:
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10 μM, 20 μM or 50 μM
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Incubation Time:
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24 hours
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Result:
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Showed a cooperative effect in cell apoptosis.
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Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1 (NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth.
Animal Model:
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Nude mice injected with human MTC cells
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Dosage:
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200 mg/kg
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Administration:
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Intraperitoneal injection; every 2 days; 12 days
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Result:
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Resulted in an average 55% inhibition of tumor growth in SBHA treatment group.
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软木肟酸
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-W009776 | 软木肟酸 Suberoyl bis-hydroxamic acid | 38937-66-5 | 50mg | 100元 |
2024/01/25 | HY-W009776 | 软木肟酸 Suberoyl bis-hydroxamic acid | 38937-66-5 | 10mM * 1mLin DMSO | 110元 |
软木肟酸
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38937-66-5, 软木肟酸 相关搜索:
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- -CH23CONHOH2
- N1,N8-二羟基辛烷二酰胺
- 次异羟肟酸
- 软木肟酸
- 辛烷-1,8-二氧肟酸
- 38937-66-5
- SuberoylBis-hydroxamicAci
- suberic bishydroxamic acid
- SBHA - CAS 38937-66-5 - Calbiochem
- N1,N8-Dihydroxyoctanediamide
- N,N′-Dihydroxyoctanediamide
- SuberohydroxaMic acid 95%
- Octanediamide, N1,N8-dihydroxy-
- Octane-1,8-dihydroxamic acid (ODHA)
- [PTYR705]-STAT3
- STAT3 (PTYR705)
- SUBEROYL BISHYDROXAMIC ACID
- SUBEROHYDROXAMIC ACID
- SUBERIC BISHYDROXAMATE
- SBHA
- OCTANE-1,8-DIHYDROXAMIC ACID
- ODHA