4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
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- CAS号:
- 170846-89-6
- 英文名:
- E4CPG
- 英文别名:
- E4CPG;(RS)-α-Ethyl-4-carboxyphenylglycine;4-(1-amino-1-carboxypropyl)benzoic acid;(RS)-ALPHA-ETHYL-4-CARBOXYPHENYLGLYCINE;Benzeneacetic acid, α-amino-4-carboxy-α-ethyl-;Metabotropic glutamate receptors,metabotropic,Inhibitor,mGluR,mGluRs,inhibit,(RS)-ECPG,E4CPG,E-4CPG
- 中文名:
- 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
- 中文别名:
- 化合物E4CPG
- CBNumber:
- CB6692522
- 分子式:
- C11H13NO4
- 分子量:
- 223.23
- MOL File:
- Mol file
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4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID化学性质
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沸点:
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431.3±40.0 °C(Predicted)
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密度:
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1.337±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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H2O : < 0.1 mg/mL (insoluble)DMSO : < 1 mg/mL (insoluble or slightly soluble)
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形态:
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Powder
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酸度系数(pKa):
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1.76±0.10(Predicted)
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4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID性质、用途与生产工艺
E4CPG ((RS)-ECPG) 是一种 Group I/Group II 代谢型谷氨酸受体 (Group I/Group II metabotropic glutamate receptor) 的拮抗剂。E4CPG 可以抑制单突触后机制中突触后电流 (IPSC) 增强的成对脉冲比。
E4CPG acts at rat cortical mGluR with the K
B
value of 0.367 mM.
E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) .
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats.
Animal Model:
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Male Swiss mice (25-35 g)
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Dosage:
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3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.)
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Administration:
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Single injection
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Result:
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The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced
nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).
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Animal Model:
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Male Sprague-Dawley rats
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Dosage:
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35 nM/3.5 μL
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Administration:
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Single injection, i.c.v.
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Result:
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Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).
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4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-100372 | E4CPG | | 1 mg | 300元 |
2024/01/25 | HY-100372 | 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG | 170846-89-6 | 5mg | 750元 |
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
生产厂家
170846-89-6, 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID 相关搜索:
- Glutamate receptor
- 170846-69-6
- 化合物E4CPG
- 170846-89-6
- Metabotropic glutamate receptors,metabotropic,Inhibitor,mGluR,mGluRs,inhibit,(RS)-ECPG,E4CPG,E-4CPG
- Benzeneacetic acid, α-amino-4-carboxy-α-ethyl-
- 4-(1-amino-1-carboxypropyl)benzoic acid
- (RS)-α-Ethyl-4-carboxyphenylglycine
- (RS)-ALPHA-ETHYL-4-CARBOXYPHENYLGLYCINE
- E4CPG