异胡芦巴核苷
|
|
- CAS号:
- 16220-07-8
- 英文名:
- ALLOPURINOL RIBOSIDE
- 英文别名:
- 8-AZA-7-DEAZAINOSINE;ALLOPURINOL RIBOSIDE;Phloretin Impurity 9;Allopurinol ribonucleoside;Allopurinol-1-ribonucleoside;8-aza-7-deaza inosine, Allopurinol riboside;1-BETA-D-RIBOFURANOSYLPYRAZOLO[3,4-D]PYRIMIDIN-4-ONE;1-β-D-ribofuranosylpyrazolo<3,4-d>pyrimidin-4(5H)-one;1-β-d-ribofuranosyl-1h-pyrazolo[3,4-d]pyrimidine-4-one;1-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE-4-ONE
- 中文名:
- 异胡芦巴核苷
- 中文别名:
- 别嘌醇核糖;异胡芦巴核苷;别嘌呤醇核糖苷;化合物 T13539;ALLOPURINOL 核苷;8-AZA-7-DEAZAINOSINE,ALLOPURINOLRIBOSIDE别嘌呤醇核糖苷
- CBNumber:
- CB6703127
- 分子式:
- C10H12N4O5
- 分子量:
- 268.23
- MOL File:
- 16220-07-8.mol
|
|
|
异胡芦巴核苷化学性质
-
沸点:
-
715.0±60.0 °C(Predicted)
-
|
-
密度:
-
2.08±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMSO:5.0(Max Conc. mg/mL);18.64(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);18.64(Max Conc. mM)-
|
-
形态:
-
A solid
-
|
-
酸度系数(pKa):
-
8.65±0.10(Predicted)
-
|
异胡芦巴核苷性质、用途与生产工艺
Allopurinol riboside是别嘌呤醇的代谢物,能有效地抑制寄生虫。
Human Endogenous Metabolite
|
Allopurinol-riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a K
i
of 277 μM. Lymphocyte blastogensis induced by PHA and Con A is significantly suppressed by allopurinol-riboside in a concentration-dependent manner. When LPS is used as a mitogen, the inhibition of allopurinol-ribosideon lymphocyte proliferation is less marked. Humoral immunity is not suppressed by allopurinol-riboside. Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Allopurinol riboside is effective against parasites, because a series of enzymes (analogous to those that mediate purine salvage in humans) convert it into 4-aminopyrazolopyrimidine ribonucleoside triphosphate, a cytotoxic product. Allopurinol riboside is selectively toxic, because it is not metabolized by the corresponding enzymes in humans.
Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range. After oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma.
异胡芦巴核苷
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/01/25 | HY-101397 | Allopurinol riboside | | 1 mg | 548元 |
2024/01/25 | HY-101397 | 异胡芦巴核苷 Allopurinol riboside | 16220-07-8 | 5mg | 1200元 |
16220-07-8, 异胡芦巴核苷 相关搜索:
- 抑制剂
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
- BioChemical
- Biochemicals and Reagents
- 8-AZA-7-DEAZAINOSINE,ALLOPURINOLRIBOSIDE别嘌呤醇核糖苷
- 别嘌醇核糖
- 化合物 T13539
- 异胡芦巴核苷
- ALLOPURINOL 核苷
- 别嘌呤醇核糖苷
- 16220-07-8
- 1-β-D-ribofuranosylpyrazolo<3,4-d>pyrimidin-4(5H)-one
- Phloretin Impurity 9
- Allopurinol riboside,inhibit,Drug Metabolite,Inhibitor,Parasite,Endogenous Metabolite
- 8-aza-7-deaza inosine, Allopurinol riboside
- 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
- Allopurinol ribonucleoside
- 1,5-Dihydro-1-β-D-ribofuranosyl-4H-pyrazolo[3,4-d]pyrimidin-4-one
- 1-[(2S,3S,4R,5R)-3,4,5,6-tetrahydroxyoxan-2-yl]-2H-pyrazolo[4,5-e]pyrimidin-4-one
- 1-β-d-ribofuranosyl-1h-pyrazolo[3,4-d]pyrimidine-4-one
- 8-AZA-7-DEAZAINOSINE
- ALLOPURINOL RIBOSIDE
- 1-BETA-D-RIBOFURANOSYLPYRAZOLO[3,4-D]PYRIMIDIN-4-ONE
- 1-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE-4-ONE
- Allopurinol-1-ribonucleoside