椭圆玫瑰树碱
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- CAS号:
- 519-23-3
- 英文名:
- ELLIPTICINE
- 英文别名:
- K00071;icig770;CP-3025;LP00531;CS-1794;CCG36483;NSC-71795;CCG 36483;CCG-36483;DB-052047
- 中文名:
- 椭圆玫瑰树碱
- 中文别名:
- 玫瑰树碱;椭圆玫瑰树碱;椭圆玫瑰树碱溶液;玫瑰树碱/椭圆玫瑰树碱;玫瑰树碱(甄准不供应);5,11-二甲基-6H-吡啶并[4,3-B]咔唑;玫瑰树碱, 一种有效的抗肿瘤剂, 抑制 DNA拓扑异构酶II 活性
- CBNumber:
- CB6746832
- 分子式:
- C17H14N2
- 分子量:
- 246.31
- MOL File:
- 519-23-3.mol
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椭圆玫瑰树碱化学性质
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熔点:
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316-318°C
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沸点:
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379.31°C (rough estimate)
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密度:
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1.257±0.06 g/cm3 (20 ºC 760 Torr)
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折射率:
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1.5794 (estimate)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble
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形态:
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Bright yellow solid
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酸度系数(pKa):
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16.59±0.40(Predicted)
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Merck:
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13,3581
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LogP:
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4.800
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CAS 数据库:
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519-23-3(CAS DataBase Reference)
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椭圆玫瑰树碱性质、用途与生产工艺
Ellipticine (NSC 71795) 是一种有效的抗肿瘤剂; 抑制 DNA拓扑异构酶II 活性。
Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.
Ellipticine (NSC 71795) treatment results in Ellipticine (NSC 71795)-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b
5
protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b
5
may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).
椭圆玫瑰树碱
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15753 | Ellipticine | | 5 mg | 600元 |
| 2024/01/25 | HY-15753 | Ellipticine | | 10 mg | 900元 |
椭圆玫瑰树碱
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全球有 110家供应商
椭圆玫瑰树碱国内生产厂家
519-23-3, 椭圆玫瑰树碱 相关搜索:
- Antitumour
- Indoles and derivatives
- Alkaloids
- Inhibitors
- 酶
- 对照品
- 抑制剂
- 小分子抑制剂
- 小分子抑制剂，天然产物
- 植物提取物
- BioChemical
- Biochemicals and Reagents
- Apoptosis and Cell Cycle
- Cell Biology
- Cell Signaling and Neuroscience
- DNA Repair Regulators
- Nucleic Acid Stains For Flow Cytometry
- Nucleic Acid Stains
- Fluorescent Stains
- Fluorescent Probes, Labels, Particles and Stains
- DNA metabolism
- 玫瑰树碱, 一种有效的抗肿瘤剂, 抑制 DNA拓扑异构酶II 活性
- 玫瑰树碱/椭圆玫瑰树碱
- 玫瑰树碱(甄准不供应)
- 椭圆玫瑰树碱
- 玫瑰树碱
- 椭圆玫瑰树碱溶液
- 5,11-二甲基-6H-吡啶并[4,3-B]咔唑
- 519-23-3
- Ellipticine,Inhibitor,NSC71795,NSC-71795,Topoisomerase,inhibit
- Ellipticine - CAS 519-23-3 - Calbiochem
- CS-1794
- VZ29809. elliptecine
- TCMDC-125546
- LS-133282
- LP00531
- K00071
- Elliptisine
- DB-052047
- CCG-36483; CCG36483; CCG 36483; BRN-0221300; BRN0221300; BRN 0221300; DB-052047; K00071; LP00531; LS-133282; NSC 71795; NSC71795; NSC-71795; TCMDC-125546; VZ29809. ELLIPTECINE; ELLIPTICINE; ELLIPTISINE
- CCG-36483
- CCG36483
- CCG 36483
- Ellipticine, ≥99%
- 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole Ellipticine
- Ellipticine,5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
- Ccris 2003
- Brn 0221300
- 6H-Pyrido(4,3-B)carbazole, 5,11-dimethyl-
- 55042-50-7 (Tartrate)
- 33668-12-1 (Hydrochloride)
- Ellipticine Solution
- NSC-71795
- CP-3025
- PYRIDO(4,3-B)CARBAZOLE,5,11-DIMETHYL-
- ELLIPTICIN
- ELLIPTICINE(RG)
- ELLIPTICINE, FOR FLUORESCENCE