139290-65-6
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- CAS号:
- 139290-65-6
- 英文名:
- (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
- 英文别名:
- M 100907;MDL100907;R-MDL 100907;VOLINANSERIN;MDL 100907 NEW;MDL100907-L-tartrate;MDL100907 tartrate salt;MDL 100907
(MDL-100907;MDL-100907(Volinanserin);Volinanserin (MDL100907)
- 中文名:
- 139290-65-6
- 中文别名:
- 氟利色林;诺和灵 M100907;VOLINANSERIN MDL 100907 (R构型);Volinanserin MDL 100907 (R构型);(R)-(2,3-二甲氧基苯基)(1-(4-氟苯乙基)哌啶-4-基)甲醇
- CBNumber:
- CB7103504
- 分子式:
- C22H28FNO3
- 分子量:
- 373.46
- MOL File:
- 139290-65-6.mol
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139290-65-6化学性质
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熔点:
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89-91°C
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沸点:
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499.4±45.0 °C(Predicted)
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密度:
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1.150±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥20mg/mL
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形态:
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powder
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酸度系数(pKa):
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13.93±0.20(Predicted)
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颜色:
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off-white to light brown
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139290-65-6性质、用途与生产工艺
Volinanserin (Volinanserin Hydrochloride Salt, MDL100907, M 100907, MDL-100,907)是一种高度选择性的、有效的 5-HT2 receptor 的拮抗剂,其Ki值为0.36 nM。Volananserin 具有治疗精神紊乱的药物活性。
Target | Value |
5-HT2 receptor
(Cell-free assay)
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0.36 nM(Ki)
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Volinanserin (MDL 100907) is a potent antagonist at the 5-HT
2
receptor, with a K
i
of 0.36 nM, and shows 300-fold selectivity for 5-HT
2
receptor over 5-HT
1c
receptor, alpha-1 and DA D
2
receptors. Volinanserin has antipsychotic activity.
Volinanserin (MDL 100907; 0.008-2.0 mg/kg, i.p.) significantly decreases d-amphetamine-stimulated locomotor activity in mice, with an ED
50
of 0.3 mg/kg, but shows no obvious reduction in the base-line locomotor activity in mice. Volinanserin produces atalepsy with an ED
50
of 10-50 mg/kg in rats. Volinanserin does not reduces apomorphine-induced stereotypies or produces catalepsy in rats. Volinanserin (M100907) combined with MK-801 significantly decreases reinforcers at 1 μg/kg, but dose-dependently (10, 100 μg/kg) antagonizes the disruptive effect of MK-801 in rats via i.p. administration. Volinanserin (6.25 μg/kg) enhances the antidepressant-like action of desipramine in rats performing under a DRL 72-s schedule, and elevates the antidepressant-like effect of tranylcypromine.
139290-65-6
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-14940 | Volinanserin | | 1 mg | 500元 |
2024/01/25 | HY-14940 | 139290-65-6 Volinanserin | 139290-65-6 | 5mg | 1100元 |
139290-65-6, 139290-65-6 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- C22H28FNO3
- C22H28FNO3C4H6O6
- C22H29ClFNO3
- (R)-(2,3-二甲氧基苯基)(1-(4-氟苯乙基)哌啶-4-基)甲醇
- 诺和灵 M100907
- 氟利色林
- VOLINANSERIN MDL 100907 (R构型)
- Volinanserin MDL 100907 (R构型)
- 139290-65-6
- 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αR)-
- Serotonin Receptor,inhibit,MDL 100907,5-HT Receptor,M-100907,5-hydroxytryptamine Receptor,Inhibitor,Volinanserin,M100907,MDL-100907
- Volinanserin (MDL100907)
- MDL 100907 NEW
- MDL 100907
(MDL-100907
- (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol
- VOLINANSERIN
- (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
- 4-PIPERIDINEMETHANOL, 1-[2-(4-FLUOROPHENYL)ETHYL]-ALPHA-(2,3-DIMETHOXYPHENYL)-, (ALPHAR)
- MDL100907
- 4-piperidinemethanol, a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (ar)-
- (R)-(2,3-dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol
- (R)-(+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol
- MDL-100907(Volinanserin)
- (αR)-α-(2,3-DiMethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidineMethanol Hydrochloride
- (+)-α-(2,3-DiMethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidineMethanol Hydrochloride
- Volinanserin Hydrochloride Salt
- (aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol Hydrochloride
- (+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol Hydrochloride
- MDL100907 tartrate salt
- 4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R)
- (R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol
- MDL100907-L-tartrate
- 4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R), (R,R)-tartrate
- (R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol (R,R)-tartrate
- R-MDL 100907
- M 100907
- (aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
- (+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol