ABAPERIDONE
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- CAS号:
- 183849-43-6
- 英文名:
- ABAPERIDONE
- 英文别名:
- ABAPERIDONE;4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)-
- 中文名:
- ABAPERIDONE
- 中文别名:
- 阿巴哌酮;化合物 T14083
- CBNumber:
- CB71092474
- 分子式:
- C25H25FN2O5
- 分子量:
- 452.47
- MOL File:
- 183849-43-6.mol
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ABAPERIDONE化学性质
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沸点:
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667.3±55.0 °C(Predicted)
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密度:
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1.320±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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13.48±0.10(Predicted)
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ABAPERIDONE性质、用途与生产工艺
Abaperidone 是一种有效的 5-HT2A 受体和多巴胺 D2 受体拮抗剂，IC50 分别为 6.2 和 17 nM。
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D
2
Receptor
17 nM (IC
50
)
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5-HT
2A
Receptor
6.2 nM (IC
50
)
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Abaperidone possesses good affinity for dopamine D
2
receptors, together with a greater affinity for 5-HT
2
receptors with IC
50
of 17 and 6.2 nM, reaspectively.
The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs.
ABAPERIDONE
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101619 | Abaperidone | | 1 mg | 3995元 |
183849-43-6, ABAPERIDONE 相关搜索:
- 化合物 T14083
- 阿巴哌酮
- 183849-43-6
- 4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)-
- ABAPERIDONE