托泊地芬
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- CAS号:
- 15790-02-0
- 英文名:
- Tropodifene
- 英文别名:
- Tropaphen;Tropodifene;(8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-(4-acetyloxyphenyl)-2-phenylpropanoate;Benzenepropanoic acid, 4-(acetyloxy)-α-phenyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
- 中文名:
- 托泊地芬
- 中文别名:
- 托泊地芬;化合物 T13211;化合物 TROPODIFENE
- CBNumber:
- CB71117388
- 分子式:
- C25H29NO4
- 分子量:
- 407.507
- MOL File:
- 15790-02-0.mol
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托泊地芬化学性质
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沸点:
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508.5±50.0 °C(Predicted)
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密度:
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1.20±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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9.99±0.40(Predicted)
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托泊地芬性质、用途与生产工艺
Tropodifene (Tropaphen) 是α-肾上腺素能受体 (α-Adrenergic receptor) 抑制剂。
Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits.
托泊地芬
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15790-02-0, 托泊地芬 相关搜索:
- 抑制剂
- C25H29NO4
- 化合物 TROPODIFENE
- 化合物 T13211
- 托泊地芬
- 15790-02-0
- (8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-(4-acetyloxyphenyl)-2-phenylpropanoate
- Benzenepropanoic acid, 4-(acetyloxy)-α-phenyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
- Tropaphen
- Tropodifene