CS-1374
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- CAS号:
- 124689-65-2
- 英文名:
- Cryptophycin
- 英文别名:
- CS-1374;Cryptophycin;cryptophycin 1;Cyclo[(2R)-2-methyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-5-hydroxy-6-[(2R,3R)-3-phenyl-2-oxiranyl]-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl]
- 中文名:
- CS-1374
- 中文别名:
- CBNumber:
- CB71120195
- 分子式:
- C35H43ClN2O8
- 分子量:
- 655.19
- MOL File:
- 124689-65-2.mol
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CS-1374化学性质
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比旋光度:
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White or light colored glassy solid. D +33.8° (c = 1.83 in methanol)
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沸点:
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889.4±65.0 °C(Predicted)
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密度:
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1.171±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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12.83±0.70(Predicted)
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CS-1374性质、用途与生产工艺
Cryptophycin 1 是一种从 Nostoc sp. 中分离出来的有效的细胞毒性抗微管剂。Cryptophycin 1 可以诱导细胞凋亡，并具有抗肿瘤活性和出色的抗增殖能力。
Cryptophycin 1 (50 pM) rapidly causes morphological changes consistent with the induction of apoptosis in SKOV3 and MDA-MB-435 cells.
Cryptophycin 1 (50 pM; 12-24 h) causes an accumulation of MDA-MB-435 cells in G2/M.
Cryptophycin 1 (100 nM; 1-7 min) markedly reduces the rates and extents of microtubule shortening and growing events and dramatically increases the duration of phases of attenuation or pause.
Apoptosis Analysis
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Cell Line:
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SKOV3 cells
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Concentration:
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50 pM
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Incubation Time:
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4 hours
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Result:
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Caused rapid cell shrinkage, loss of the normal elliptical spheroid shape and the formation of membrane blebs.
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Cell Cycle Analysis
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Cell Line:
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MDA-MB-435 cells
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Concentration:
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50 pM
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Incubation Time:
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12, 18, 24 hours
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Result:
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A doubling in the number of cells in G
2
/M at 12 hr.
Still a large number of cells (58%) in G
2
/M at 18 hr.
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Cryptophycin 1 (i.v.) exhibits anti-tumor activity in mice.
CS-1374
上下游产品信息
上游原料
下游产品
124689-65-2, CS-1374 相关搜索:
- C35H43ClN2O8
- 124689-65-2
- Cyclo[(2R)-2-methyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-5-hydroxy-6-[(2R,3R)-3-phenyl-2-oxiranyl]-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl]
- CS-1374
- cryptophycin 1
- Cryptophycin