N-去甲基三苯氧胺 盐酸盐
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- CAS号:
- 15917-65-4
- 英文名:
- N-Desmethyl Tamoxifen Hydrochloride
- 英文别名:
- Nsc372964;Tamoxifen EP Impurity F HCl;N-Demethyltamoxifen Hydrochlorid;2-[4-[(Z)-1,2-Diphenylbut-1-enyl]ph;Tamoxifen Citrate EP Impurity F HCl;Tamoxifen Citrate Impurity F as Hydrochloride;Tamoxifen Citrate EP Impurity F as Hydrochloride;(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine;Tamoxifen Citrate Impurity 6(Tamoxifen Citrate EP Impurity F);Tamoxifen Citrate Impurity 6(Tamoxifen Citrate EP Impurity F HCl)
- 中文名:
- N-去甲基三苯氧胺 盐酸盐
- 中文别名:
- 枸橼酸他莫昔芬杂质6;N-去甲他莫昔芬盐酸盐;N-去甲基他莫昔芬盐酸;盐酸他莫昔芬EP杂质F;他莫昔芬杂质F (EP);他莫昔芬EP杂质F HCL;N-去甲基三苯氧胺 盐酸盐;枸橼酸他莫昔芬杂质F(EP) 标准品;N-去甲基三苯氧胺 盐酸盐/N-去甲基他莫昔芬盐酸盐;2-[4-[(1Z)-1,2-二苯基-1-丁烯基]苯氧基]-N-甲基乙胺盐酸盐
- CBNumber:
- CB71176581
- 分子式:
- C25H27NO.ClH
- 分子量:
- 393.955
- MOL File:
- 15917-65-4.mol
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N-去甲基三苯氧胺 盐酸盐化学性质
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熔点:
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225-227°C
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储存条件:
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room temp
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溶解度:
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DMSO: ≥20mg/mL
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形态:
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solid
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稳定性:
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Light sensitive
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N-去甲基三苯氧胺 盐酸盐性质、用途与生产工艺
N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内的主要代谢产物。N-Desmethyltamoxifen,较弱的抗雌激素,是一种比 Tamoxifen 强十倍的蛋白激酶 C (PKC) 抑制剂。N-Desmethyltamoxifen hydrochloride 也是人体 AML 细胞神经酰胺代谢的有效调节因子,限制神经酰胺糖基化、水解和鞘氨醇磷酸化。
N-desmethyltamoxifen hydrochloride (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
N-desmethyltamoxifen hydrochloride (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen hydrochloride, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.
Cell Viability Assay
Cell Line:
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MCF 7 human mammary carcinoma cells
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Concentration:
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1.5, 2.5, 5, 7.5, 10 μM
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Incubation Time:
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114 hours
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Result:
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Inhibits growth of MCF 7 human mammary carcinoma cells
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N-去甲基三苯氧胺 盐酸盐
上下游产品信息
上游原料
下游产品
15917-65-4, N-去甲基三苯氧胺 盐酸盐 相关搜索:
- Various Metabolites and Impurities
- Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- 杂质对照品
- C25H28ClNO
- 他莫昔芬EP杂质F HCL
- (Z)-2-(4-(1,2-二苯基丁-1-烯-1-基)苯氧基)-N-甲基乙胺盐酸盐
- 盐酸他莫昔芬EP杂质F
- 枸橼酸他莫昔芬杂质6
- 枸橼酸他莫昔芬杂质F(EP) 标准品
- 他莫昔芬杂质F (EP)
- N-去甲他莫昔芬盐酸盐
- N-去甲基他莫昔芬盐酸
- N-去甲基三苯氧胺 盐酸盐
- N-去甲基三苯氧胺 盐酸盐/N-去甲基他莫昔芬盐酸盐
- 2-[4-[(1Z)-1,2-二苯基-1-丁烯基]苯氧基]-N-甲基乙胺盐酸盐
- 15917-65-4
- Tamoxifen Citrate Impurity F as Hydrochloride
- Tamoxifen Citrate EP Impurity F as Hydrochloride
- PKC,sphingosine,inhibit,N-Desmethyltamoxifen,NDesmethyltamoxifen hydrochloride,cells,Protein kinase C,Inhibitor,phosphorylation,metabolism,Estrogen Receptor/ERR,carcinoma,AML,Drug Metabolite,ceramide,N Desmethyltamoxifen hydrochloride,Endogenous Metabolite,metabolite,antiestrogen
- 2-[4-[(Z)-1,2-Diphenylbut-1-enyl]phenoxy]-N-methylethanamine Hydrochloride
- (Z)-2-(4-(1,2-Diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine hydrochloride
- Tamoxifen Citrate Impurity 6(Tamoxifen Citrate EP Impurity F)
- Tamoxifen Citrate Impurity 6(Tamoxifen Citrate EP Impurity F HCl)
- Tamoxifen EP Impurity F HCl
- 2-[4-[(Z)-1,2-Diphenylbut-1-enyl]ph
- Tamoxifen Citrate EP Impurity F HCl
- (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine
- 2-[4-[(1Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N-methylethanamine hydrochloride
- Nsc372964
- (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N-methylethanamine Hydrochloride
- N-Demethyltamoxifen Hydrochlorid