化合物 T15800
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- CAS号:
- 63676-25-5
- 英文名:
- Phenethipylone
- 英文别名:
- LY 117018;Ly 139478;Lilly 117018;Phenethipylone;LY-117018,LY117018;6-Hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl 4-(2-(1-pyrrolidinyl)ethoxy) phenyl ketone;[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone;Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone
- 中文名:
- 化合物 T15800
- 中文别名:
- 化合物 T15800
- CBNumber:
- CB71179481
- 分子式:
- C27H25NO4S
- 分子量:
- 459.56
- MOL File:
- 63676-25-5.mol
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化合物 T15800性质、用途与生产工艺
LY117018，Raloxifene 类似物，是一种选择性雌激素受体 (estrogen receptor) 调节剂。LY117018 对乳腺癌细胞具有抗增殖作用。
LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation.
LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC
50
of 1 μM.
LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.
Cell Proliferation Assay
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Cell Line:
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MCF-7 cells
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Concentration:
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1 μM
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Incubation Time:
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96 hours
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Result:
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Inhibited MCF-7 cells proliferation with an IC
50
of 1 μM.
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化合物 T15800
上下游产品信息
上游原料
下游产品
63676-25-5, 化合物 T15800 相关搜索:
- 化合物 T15800
- 63676-25-5
- LY-117018,LY117018
- [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone
- Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-
- Ly 139478
- Lilly 117018
- 6-Hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl 4-(2-(1-pyrrolidinyl)ethoxy) phenyl ketone
- [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone
- LY 117018
- Phenethipylone