艾美拉唑钾盐
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- CAS号:
- 161796-84-5
- 英文名:
- Esomeprazole potassium
- 英文别名:
- Esomeprazole potassium;(S)-Omeprazole potassium;Esomeprazole potassium USP/EP/BP;(S)-5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d];potassium,5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;(R)-5-METHOXY-2-((4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYLSULFINYL)BENZO[D]IMIDAZOL-1-IDE POTASSIUM SALT;6-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole potassium salt (1:1);1H-Benzimidazole,6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,potassium salt (1:1)
- 中文名:
- 艾美拉唑钾盐
- 中文别名:
- 埃索拉唑钾盐;埃索美拉唑钾;艾美拉唑钾盐;埃索美拉唑钾盐;化合物 ESOMEPRAZOLE POTASSIUM SALT;6-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基]-1H-苯并咪唑钾盐;6-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基]-1H-苯并咪唑钾盐 (1:1)
- CBNumber:
- CB71229920
- 分子式:
- C17H20KN3O3S
- 分子量:
- 385.52
- MOL File:
- 161796-84-5.mol
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艾美拉唑钾盐化学性质
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蒸气压:
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0Pa at 25℃
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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艾美拉唑钾盐性质、用途与生产工艺
艾美拉唑钾盐是一种质子泵抑制剂,艾美拉唑钾盐是奥美拉唑的S-异构体,通过特异性的质子泵抑制作用减少胃酸分泌,奥美拉唑的R-异构体和S-异构体具有相似的药效学特性。艾美拉唑钾盐为弱碱性药物,在壁细胞泌酸微管的高酸环境中浓集并转化为活性形式,从而抑制该部位的H+/K+-ATP酶(质子泵),对基础胃酸分泌和受刺激后的胃酸分泌均产生抑制。
艾美拉唑钾盐盐是通过艾美拉唑钾盐成盐得到的,艾美拉唑钾盐盐能够降低对机体的刺激性,并且在机体中具有良好的溶解性,提高生物利用度,从而能够产生更理想的药理作用,常见的艾美拉唑钾盐盐主要有艾美拉唑钾盐钠盐、艾美拉唑钾盐钾盐、艾美拉唑钾盐镁盐。目前,艾美拉唑钾盐盐主要通过艾美拉唑钾盐成盐得到,因此,艾美拉唑钾盐的制备方法不仅影响艾美拉唑钾盐的纯度,而且影响艾美拉唑钾盐盐的纯度。
Esomeprazole potassium salt ((S)-Omeprazole potassium salt) 是一种有效的具有口服活性质子泵抑制剂,可通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌,并可用于胃食管反流疾病的研究。
Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification.
Cell Viability Assay
Cell Line:
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MDA-MB-468 cells
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Concentration:
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25 µM, 50 µM, 75 µM, 100 µM
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Incubation Time:
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20 hours
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Result:
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Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.
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Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis.
Animal Model:
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C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury
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Dosage:
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30 mg/kg, 300 mg/kg
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Administration:
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Oral gavage; daily; for 19 or 11 days
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Result:
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Significantly inhibited the progression of fibrosis throughout the lungs of the animals.
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艾美拉唑钾盐
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161796-84-5, 艾美拉唑钾盐 相关搜索:
- 标准品
- 原料药
- 医用原料
- 医药原料药
- 化合物 ESOMEPRAZOLE POTASSIUM SALT
- 埃索美拉唑钾盐
- 艾美拉唑钾盐
- 6-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基]-1H-苯并咪唑钾盐 (1:1)
- 6-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基]-1H-苯并咪唑钾盐
- 埃索拉唑钾盐
- 埃索美拉唑钾
- 161796-84-5
- Esomeprazole potassium USP/EP/BP
- 1H-Benzimidazole,6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,potassium salt (1:1)
- potassium,5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
- (S)-5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]
- (R)-5-METHOXY-2-((4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYLSULFINYL)BENZO[D]IMIDAZOL-1-IDE POTASSIUM SALT
- Esomeprazole potassium
- 6-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole potassium salt (1:1)
- (S)-Omeprazole potassium