4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
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- CAS号:
- 68592-15-4
- 英文名:
- 4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol
- 英文别名:
- 4-O-Methyl honokiol;4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol;4'-Methoxy-3',5-di-2-propen-1-yl[1,1'-biphenyl]-2-ol;2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol;[1,1'-Biphenyl]-2-ol, 4'-methoxy-3',5-di-2-propen-1-yl-
- 中文名:
- 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
- 中文别名:
- 4-O-和厚朴酚;4-甲基和厚朴酚;化合物 T10153;4--O-甲基和厚朴酚;4-甲氧基-3,5-二丙烯基-(1,1'-联苯)-2-醇;4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
- CBNumber:
- CB71401542
- 分子式:
- C19H20O2
- 分子量:
- 280.36
- MOL File:
- 68592-15-4.mol
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4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 33 mg/ml; DMSO: 33 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
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4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇性质、用途与生产工艺
4-O-Methyl honokiol 是从厚朴中分离到的木脂素类化合物，为 PPARγ 的激动剂，可抑制 NF-κB 的活性，用于癌症，炎症等研究。
4-O-Methyl honokiol is a natural neolignan isolated from
Magnolia officinalis
, acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells.
4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues. 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ
1-42
accumulation, and activates astrocytes and microglia in LPS-injected mice brain.
用途
用于含量测定/鉴定/药理实验等。
4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-U00450 | 4-O-Methyl honokiol | | 1 mg | 681元 |
| 2024/01/25 | HY-U00450 | 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
4-O-Methyl honokiol | 68592-15-4 | 5mg | 1500元 |
4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
生产厂家
68592-15-4, 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇 相关搜索:
- 小分子药物
- 标准品
- 8592-15-4
- 4-甲基和厚朴酚
- 化合物 T10153
- 4--O-甲基和厚朴酚
- 4-O-和厚朴酚
- 4-甲氧基-3,5-二丙烯基-(1,1'-联苯)-2-醇
- 4'-甲氧基-3',5-二-2-丙烯基-(1,1'-联苯)-2-醇
- 68592-15-4
- 4'-Methoxy-3',5-di-2-propen-1-yl[1,1'-biphenyl]-2-ol
- [1,1'-Biphenyl]-2-ol, 4'-methoxy-3',5-di-2-propen-1-yl-
- 4-O-Methyl honokiol
- 2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
- 4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol