1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐
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- CAS号:
- 85375-15-1
- 英文名:
- 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
- 英文别名:
- skf-89976a;SKF89976AHCl;SKF 89976A HYDROCHLORIDE;l-SKF89976A hydrochloride;d,l-SKF89976A hydrochloride;1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE;1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride;1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride;Gamma-aminobutyric acid Receptor,γ-Aminobutyric acid Receptor,d,l-SKF89976A,GABA Receptor,SKF89976A,inhibit,SKF89976A hydrochloride,Inhibitor,SKF-89976A hydrochloride
- 中文名:
- 1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐
- 中文别名:
- 4-二苯基-3-丁烯基)-3-哌啶盐酸盐;化合物SKF89976A HYDROCHLORIDE;1-(4,4-二苯基丁-3-烯-1-基)哌啶-3-羧酸盐酸盐;1-(4,4-二苯基-3-丁烯-1-基)-3-哌啶甲酸盐酸盐;1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐
- CBNumber:
- CB7194179
- 分子式:
- C22H26ClNO2
- 分子量:
- 371.9
- MOL File:
- 85375-15-1.mol
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1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐化学性质
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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DMSO: 20 mg/mL, soluble
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形态:
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solid
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颜色:
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white
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1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐性质、用途与生产工艺
SKF89976A hydrochloride 是一种选择性 GABA 转运蛋白 GAT-1 抑制剂,作用于 CHO 细胞中的 GAT-1,GAT-2 和 GAT-3,IC50 分别为 0.28 μM,137.34 μM 和 202.8 μM。
IC50: 0.28 μM (GAT-1), 137.34 μM (GAT-2), 202.8 μM (GAT-3)
SKF89976A has a weak antiallodynic action. SKF89976A weakly inhibits serotonin transporter (SERT), noradrenaline transporter (NET), and dopamine transporter (DAT) in chinese hamster ovary (CHO) cells stably expressing each transporter using a substrate uptake assay, with IC
50
values of 3514 , 202.13, and 728.8, respectively. SKF89976A is a GABA-transport blocker. GABA (1 mM) elicited an inward current that is completely suppressed by the GABA transport inhibitors tiagabine (10 μM) and SKF89976A (100 μM), but is unaffected by 100 μM picrotoxin. 100 μM SKF 89976-A is known to block the transport of GABA into cells, completely eliminated the GABA-elicited current in a reversible fashion. SKF89976A is a nontransportable blockers of GAT-1. SKF89976-A also suppresses baseline inward currents that likely result from tonic GAT activation by background GABA. SKF89976A (100 μM) reversibly reduces GAT currents in every studied cell by 67.9±4.4% (n=19). Intracellular perfusion of 20 μM SKF89976-A progressively reduced and blocked GABA-induced GAT currents without blocking GABAAR-mediated currents (n=4).
SKF89976A produces a weak antiallodynic response when administered i.v. (0.3 mg/kg). The i.t. injection of SKF89976A dose-dependently ameliorates the reduction in the withdrawal threshold in PSL model mice.
1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100228A | 1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐 SKF89976A hydrochloride | 85375-15-1 | 5mg | 660元 |
2024/08/19 | HY-100228A | 1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐 SKF89976A hydrochloride | 85375-15-1 | 10mM * 1mLin DMSO | 726元 |
1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐
生产厂家
85375-15-1, 1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐 相关搜索:
- GABA
- GABA/Glycine receptor
- 库存
- 定制化学品
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- GABA and Glycine Receptor Modulators
- Ligand-Gated Ion Channels
- Ion Channels
- C22H25NO2HCl
- 1-(4,4-二苯基丁-3-烯-1-基)哌啶-3-羧酸盐酸盐
- 化合物SKF89976A HYDROCHLORIDE
- 4-二苯基-3-丁烯基)-3-哌啶盐酸盐
- 1-(4,4-二苯基-3-丁烯-1-基)-3-哌啶甲酸盐酸盐
- 1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐
- 85375-15-1
- Gamma-aminobutyric acid Receptor,γ-Aminobutyric acid Receptor,d,l-SKF89976A,GABA Receptor,SKF89976A,inhibit,SKF89976A hydrochloride,Inhibitor,SKF-89976A hydrochloride
- l-SKF89976A hydrochloride
- d,l-SKF89976A hydrochloride
- 1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
- 1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride
- skf-89976a
- SKF89976AHCl
- 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
- SKF 89976A HYDROCHLORIDE