短杆菌素
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- CAS号:
- 1404-88-2
- 英文名:
- TYROTHRICIN
- 英文别名:
- dermotricine;tyri10;coltirot;tyroderm;martricin;solutricine;soluthricin;bactratycin;TYROTHRICIN;hydrotricine
- 中文名:
- 短杆菌素
- 中文别名:
- 短杆菌素;酪丝菌素;短杆菌素 EP标准品;短杆菌素 来源于解硫胺素芽胞杆菌 (短芽孢杆菌)
- CBNumber:
- CB7196704
- 分子式:
- C6H13NO5
- 分子量:
- 179.17112
- MOL File:
- 1404-88-2.mol
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短杆菌素化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.
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EPA化学物质信息:
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Tyrothricin (1404-88-2)
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短杆菌素性质、用途与生产工艺
Tyrothricin 是一种从短小芽孢杆菌中分离的多肽抗生素混合物，由酪氨酸和短杆菌肽组成。Tyrothricin 可抑制细菌，真菌和某些病毒的活性。含 Tyrothricin 的制剂可用于治愈咽喉痛或浅表及小面积伤口的感染。
Tyrothricin is a mixture of polypeptides, consisting of 50%-70% tyrocidines and 25%-50% gramicidins. The group of tyrocidines is basic, cyclic peptides, whereas the fraction of gramicidins is neutral, linear peptides. Besides physiological and essential L-amino acids, the components of Tyrothricin also contain D-amino acids.
Tyrothricin is produced by the gram-positive aerobic sporeforming bacterium Bacillus brevis (Strain ATCC 8185) during its sporulation phase via the nonribosomal pathway.
The efficacy spectrum of Tyrothricin mainly covers gram-positive but also several gram-negative bacteria. Corynebacteria and staphylococci show a broader range of Tyrothricin concentrations for inhibition (2-256 μg/mL). In contrast to the gramicidin fraction alone, Tyrothricin is able to inhibit all Staphylococcus strains at a maximum concentration of 128 μg/mL. Among the gram-negative organisms, gonococci and meningococci were the most sensitive germs (96 μg/mL).
Tyrothricin exerts fungicidal effects on a variety of Candida species.
Tyrothricin shows an anti-infectious activity against parainfluenza virus (type Sendai).
In animal models using HSV type 1, a pre-incubation of the virus suspension with Tyrothricin could significantly decrease the lethality in mice. The effect could only be shown after a direct contact between Tyrothricin and the virus.
Nevertheless disruption of the integrity of eukaryotic membranes is observed at higher Tyrothricin concentrations in vitro. This effect is exemplified as hemolytic activity of Tyrothricin in in vitro studies and when applied to animals i.v.. In contrast to an intravenous (LD
50
mouse: 3,7 mg/kg) and an intraperitoneal (LD
50
mouse: 20-45 mg/kg) application the oral application is very well tolerated, as Tyrothricin is destroyed in the gastro-intestinal tract.
短杆菌素
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-120435 | Tyrothricin | | 1 mg | 560元 |
| 2024/01/25 | HY-120435 | 短杆菌素
Tyrothricin | 1404-88-2 | 5mg | 1320元 |
短杆菌素
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短杆菌素国内生产厂家
1404-88-2, 短杆菌素 相关搜索:
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- 微生物代谢物
- TP - TZ
- Analytical Chromatography Product Catalog
- Alphabetic
- Analytical Standards
- 酪丝菌素
- 短杆菌素 EP标准品
- 短杆菌素 来源于解硫胺素芽胞杆菌 (短芽孢杆菌)
- 短杆菌素
- 1404-88-2
- dermotricine
- TYROTHRICIN USP/EP/BP
- Tyrothricin CRS
- 3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-keto-ethyl)-9-(3-aminopropyl)-3,22,25-tris(benzyl)-15-(4-hydroxybenzyl)-6-isobutyl-12-isopropyl-2,5,8,11,14,18,21,24,27-nonaketo-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propionic acid
- tyrothricin from bacillus aneurinolyticus (bacillus brevis)
- Tyrothricine
- TYROTHRICIN
- tyroderm
- tyri10
- solutricine
- soluthricin
- martricin
- intradermtyrothricin
- 3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-azanyl-2-oxo-ethyl)-9-(3-azanylpropyl)-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-3,22,25-tris(phenylmethyl)-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid
- 3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-3,22,25-tris(phenylmethyl)-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid
- hydrotricine
- duboscrudecrystals
- coltirot
- bactratycin