里查酮 A
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- CAS号:
- 97938-31-3
- 英文名:
- (2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
- 英文别名:
- Leachiane A;Leachianone A;(-)-Vexibidin;Apoptosis,Inhibitor,Leachianone A,inhibit;2'-methoxy-5,7,4'-trihydroxy-8-lavandulylflavanone;(S)-5,7-Dihydroxy-2-(4-hydroxy-2-Methoxyphenyl)-8-((R)-5-Methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroMan-4-one;(2S)-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one;(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
- 中文名:
- 里查酮 A
- 中文别名:
- 里查酮 A;异苦参酮,勒奇黄烷酮A;(S)-5,7-二羟基-2-(4-羟基-2-甲氧基苯基)-8-((R)-5-甲基-2-(丙-1-烯-2-基)己-4- 烯-1-基)苯并二氢吡喃-4-酮
- CBNumber:
- CB72218147
- 分子式:
- C26H30O6
- 分子量:
- 438.51
- MOL File:
- 97938-31-3.mol
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里查酮 A化学性质
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沸点:
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649.7±55.0 °C(Predicted)
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密度:
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1?+-.0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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形态:
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Powder
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酸度系数(pKa):
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7.67±0.40(Predicted)
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里查酮 A性质、用途与生产工艺
Leachianone A 从槐花中分离，具有抗疟疾，抗炎和细胞毒性作用。
Leachianone A 诱导细胞凋亡 (apoptosis)。
Leachianone A (0-20 μg/ml; 24-72 hours) exhibits a marked inhibition on the survival of HepG2 cells time- and dose-dependently manner, IC
50
values are 6.9 μg/ml, 3.4 μg/ml and 2.8 μg/ml in cells with 24-, 48- and 72-hours treatment, respectively.
Leachianone A (10-30 μg/ml; 48 hours) indicates that at low concentration of LA (10 μg/ml), a substantial amount of cells is primarily in the early phase of apoptosis, at higher concentrations, induces a shift of the cell population to late apoptotic/ necrotic stage.
Leachianone A (10-30 μg/ml; 48 hours) decreases the precursor of caspase-3 in a dose-dependent manner, reduces the protein level of the pro-forms of upstream initiator caspases, caspases-8 and -9, decreases two downstream substrates, namely inhibitor of caspase-activated DNase(ICAD) and poly-ADP-ribose polymerase (PARP) in HepG2 cells.
Cell Viability Assay
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Cell Line:
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HepG2 cells
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Concentration:
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0 μg/ml, 2 μg/ml, 4 μg/ml, 6 μg/ml, 8 μg/ml, 10 μg/ml, 12 μg/ml, 14 μg/ml, 16 μg/ml, 18 μg/ml, 20 μg/ml
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Incubation Time:
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24-72 hours
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Result:
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Inhibited HepG2 cells survival.
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Apoptosis Analysis
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Cell Line:
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HepG2 cells
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Concentration:
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48 hours
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Incubation Time:
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10, 20, and 30 μg/ml
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Result:
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Induced the proportion of annexin V-stained cells in both the early and late apoptotic stage.
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Western Blot Analysis
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Cell Line:
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HepG2 cells
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Concentration:
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48 hours
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Incubation Time:
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10, 20, and 30 μg/ml
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Result:
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Decreased the protein expression of caspase-3, caspases-8 and -9, reduced ICAD and PARP protein expression.
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Leachianone A (intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days) significantly diminishes the tumor volume by 17-54% in LA-treated nude mice, when compared with those solely given the vehicle.
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Animal Model:
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Male nude mice with human hepatoma HepG2 cells
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Dosage:
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20 mg/kg; 30 mg/kg
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Administration:
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Intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days
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Result:
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Suppressed the tumor growth in vivo.
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里查酮 A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-N2281 | 里查酮 A
Leachianone A | 97938-31-3 | 1mg | 1600元 |
| 2024/01/25 | HY-N2281 | 里查酮 A
Leachianone A | 97938-31-3 | 5mg | 3500元 |
97938-31-3, 里查酮 A 相关搜索:
- 黄酮
- 标准品 -对照药材
- 植物提取物
- 标准品
- 异苦参酮,勒奇黄烷酮A
- (S)-5,7-二羟基-2-(4-羟基-2-甲氧基苯基)-8-((R)-5-甲基-2-(丙-1-烯-2-基)己-4- 烯-1-基)苯并二氢吡喃-4-酮
- 里查酮 A
- 97938-31-3
- Apoptosis,Inhibitor,Leachianone A,inhibit
- (2S)-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one
- 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
- (-)-Vexibidin
- 2'-methoxy-5,7,4'-trihydroxy-8-lavandulylflavanone
- (S)-5,7-Dihydroxy-2-(4-hydroxy-2-Methoxyphenyl)-8-((R)-5-Methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroMan-4-one
- Leachiane A
- Leachianone A
- (2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one