Δ2-头孢呋辛酯
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- CAS号:
- 123458-61-7
- 英文名:
- Δ2-Cefuroxime Axetil
- 英文别名:
- Δ2-Cefuroxime Axetil;Δ2-Cefuroxime Axetil;Cefuroxim Impurity 34;Cefuroxim Impurity 10;Cefuroxim axetil impurity A;Cefuroxime Axetil EP Impurity A;Cefuroxime Axetil Impurities (EP);Cefuroxime Axetil Impurity A (EP);(6R,7R)-1-acetoxyethyl 3-((carbamoyloxy)methyl);Cefuroxime Impurity 34(Cefuroxime Axetil EP Impurity A)
- 中文名:
- Δ2-头孢呋辛酯
- 中文别名:
- 头孢呋辛酯杂质A;Δ2-头孢呋辛酯;头孢呋辛酯有关杂质A;头孢呋辛酯EP杂质A;原料药头孢呋辛酯 杂质A;头孢呋辛酯杂质A(EP);头孢呋辛酯AXETIL EP杂质A;头孢呋辛杂质34(头孢呋辛AXETILEP杂质A);(6R,7R)-1-乙酰氧基乙基 3-((氨基甲酰氧基)甲基)-7-((Z)-2-(呋喃-2-基)-2-(甲氧基亚氨基)乙酰氨基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-3-烯-2-羧酸盐 (头孢呋辛杂质)
- CBNumber:
- CB72508510
- 分子式:
- C20H22N4O10S
- 分子量:
- 510.47
- MOL File:
- 123458-61-7.mol
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Δ2-头孢呋辛酯化学性质
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熔点:
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64-71°C
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密度:
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1.61±0.1 g/cm3(Predicted)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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8.33±0.60(Predicted)
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颜色:
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White to Pale Yellow
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稳定性:
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Hygroscopic
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Δ2-头孢呋辛酯性质、用途与生产工艺
δ2-头孢呋辛酯,即(6R,7R)-3-氨基甲酰氧基甲基-7-[(Z)-2-(呋喃-2-基)-2-甲氧基亚氨基乙酰氨基]-3-头孢烯-4-羧酸1-乙酰氧乙基酯是头孢呋辛的1-乙酰氧乙基酯。是第二代头孢菌素类广谱抗菌剂,对革兰氏阳性微生物和革兰氏阴性微生物均有良好的抗菌活性。
δ2-头孢呋辛酯乙酸乙酯溶液在真空-0.99MPa下浓缩到30%,得到δ2-头孢呋辛酯浓缩液。
在25ml异丙醚或者石油醚中,加入0.2gδ2-头孢呋辛酯晶种,快速搅拌,得到头孢呋辛酯异丙醚或者δ2-头孢呋辛酯石油醚混悬液。
在δ2-头孢呋辛酯异丙醚或者δ2-头孢呋辛酯石油醚混悬液中,用2.5h同时匀速加入上述δ2-头孢呋辛酯浓缩液和800ml异丙醚或者石油醚溶液,然后养晶1h后过滤。
将过滤得到的晶体,用40ml体积用量比为1:5的乙酸乙酯异丙醚或者乙酸乙酯石油醚溶液洗涤,再用40ml异丙醚或者石油醚洗涤,在40℃下真空干燥,得到白色产物。
将白色产物通过喷雾干燥制备成无定型δ2-头孢呋辛酯,进而可以制成胶囊、片剂、颗粒或者分散片等口服制剂。
Δ2-头孢呋辛酯
上下游产品信息
上游原料
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123458-61-7, Δ2-头孢呋辛酯 相关搜索:
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Drug Analogues
- Chiral Reagents
- Chiral Reagents, Drug Analogues, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
- 杂质对照品
- 头孢他啶杂质
- 对照品-杂质对照品
- 头孢呋辛杂质34(头孢呋辛AXETILEP杂质A)
- (6R,7R)-1-乙酰氧基乙基 3-((氨基甲酰氧基)甲基)-7-((Z)-2-(呋喃-2-基)-2-(甲氧基亚氨基)乙酰氨基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-3-烯-2-羧酸盐 (头孢呋辛杂质)
- 头孢呋辛酯有关杂质A
- 头孢呋辛酯AXETIL EP杂质A
- 头孢呋辛酯EP杂质A
- 头孢呋辛酯杂质A
- 原料药头孢呋辛酯 杂质A
- 头孢呋辛酯杂质A(EP)
- Δ2-头孢呋辛酯
- 123458-61-7
- Cefuroxim Impurity 10
- (6R,7R)-1-Acetoxyethyl 3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate (Cefuroxime Impurity)
- 1-acetoxyethyl (6R,7R)-3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate
- Cefuroxime Axetil Impurity A (EP)(Δ3-Cefuroxime Axetil)
- Δ2-Cefuroxime Axetil
- Cefuroxime Axetil EP Impurity A
- Cefuroxime Axetil Impurity A (EP)
- Cefuroxime Axetil Impurities (EP)
- Cefuroxime Impurity 34(Cefuroxime Axetil EP Impurity A)
- (6R,7R)-1-acetoxyethyl 3-((carbamoyloxy)methyl)
- Cefuroxime Axetil Impurity A (EP)(Δ3-Cefuroxime Axetil)
- 1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate
- Δ2-Cefuroxime Axetil
(Cefuroxime Axetil Delta-3 Isomer)
- 5-Thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, (6R,7R)-
- Cefuroxim Impurity 34
- Cefuroxim axetil impurity A
- [6R-[6α, 7β(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(acetyloxy)ethyl ester
- (6R,7R)-3-[[(AMinocarbonyl)oxy]Methyl]-7-[[(2Z)-2-(2-furanyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic Acid 1-(Acetyloxy)ethyl Ester
- Δ2-Cefuroxime Axetil